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Novel region within the V kappa gene promoter is responsible for tissue and stage-specific expression of immunoglobulin genes in human lymphoid neoplasms.

机译：V kappa基因启动子内的新区域负责人淋巴肿瘤中免疫球蛋白基因的组织和阶段特异性表达。

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摘要

Immunoglobulin gene-specific transacting factors have been shown to play a role in lymphoid tissue-specific expression of immunoglobulin genes. The role of these factors in B-cell differentiation and stage-specific expression of these genes is, however, not fully understood. We have used a model of human lymphoid neoplasia to address this question. Different fragments of unrearranged human variable region of immunoglobulin kappa gene (V kappa) were used for cell-free in vitro transcription and DNA mobility shift assays. Previously described enhancement of in vitro transcription that was only seen with nuclear extracts derived from B-cell neoplasms corresponding to the late stages of B-cell differentiation was shown to be dependent on the actions of these factor(s) on the DNA region within the V kappa gene promoter. This region is located within the 920 bp fragment located 210 bp upstream from the coding region and this fragment represents a possible novel DNA region, which plays a role in the stage- and tissue-specific expression of immunoglobulin genes.

机译：免疫球蛋白基因特异性交易因子已显示在免疫球蛋白基因的淋巴组织特异性表达中起作用。但是，这些因子在这些基因的B细胞分化和阶段特异性表达中的作用尚不完全清楚。我们已经使用人类淋巴瘤形成模型来解决这个问题。免疫球蛋白kappa基因（V kappa）的未重排人可变区的不同片段用于无细胞体外转录和DNA迁移率测定。先前描述的体外转录增强仅在衍生自B细胞赘生物的核提取物（对应于B细胞分化的后期）中才能看到，这取决于这些因子对DNA区域内DNA区域的作用。 Vκ基因启动子。该区域位于编码区域上游210 bp的920 bp片段内，该片段代表可能的新DNA区域，在免疫球蛋白基因的阶段和组织特异性表达中起作用。

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期刊名称 Immunology
作者
A E Kossakowska; S J Urbanski;
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作者单位

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年(卷),期 1989(66),3
年度 1989
页码 328–334
总页数 7
原文格式 PDF
正文语种
中图分类免疫学;
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Novel region within the V kappa gene promoter is responsible for tissue and stage-specific expression of immunoglobulin genes in human lymphoid neoplasms.

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