Objective: To perform a systematic review (SR) of existing literature and a patent landscape report (PLR) regarding the potential applications of shape-memory polymers (SMPs) in dentistry. Search strategy: Clinical and Biomedical online databases (Pubmed, Medline via Embase, Scopus, LILACS, Web of Science, Cochrane Library), Materials Science and Engineering databases (IEEE Explore, Compendex, Proquest), Material Science and Chemical database (Reaxys) so as Patents databases (Questel-Orbit, Espacenet, Patentscope) were consulted as recently as January 2019 to identify all papers and patents potentially relevant to the review. The reference lists of all eligible studies were hand searched for additional published work. Results: After duplicate selection and extraction procedures, 6 relevant full-text articles from the initial 302 and 45 relevant patents from 497 were selected. A modified Consolidated Standards of Reporting Trials (CONSORT) checklist of 14 items for reporting pre-clinical in-vitro studies was used to rate the methodological quality of the selected papers. The overall quality was judged low. Conclusions: Despite the great potential and versatility of SMPs, it was not possible to draw evidence-based conclusions supporting their immediate employment in clinical dentistry. This was due to the weak design and a limited number of studies included within this review and reflects the fact that additional research is mandatory to determine whether or not the use of SMPs in dentistry could be effective. Nevertheless, the qualitative analysis of selected papers and patents indicate that SMPs are promising materials in dentistry because of their programmable physical properties. These findings suggest the importance of furtherly pursuing this line of research.
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机译：目的：对形状记忆聚合物（SMP）在牙科领域的潜在应用进行现有文献的系统综述（SR）和专利态势报告（PLR）。搜索策略：临床和生物医学在线数据库（公开，通过Embase获得Medline，Scopus，LILACS，Web of Science，Cochrane图书馆），材料科学和工程数据库（IEEE Explore，Compendex，Proquest），材料科学和化学数据库（Reaxys）等作为专利数据库（Questel-Orbit，Espacenet，Patentscope）的最新信息，已于2019年1月进行了咨询，以确定所有可能与该审查相关的论文和专利。手工搜索所有符合条件的研究的参考文献列表，以查找其他已发表的著作。结果：经过重复的选择和提取程序，从最初的302种专利中选择了6条相关的全文，从497条中选择了45条相关的专利。修改后的14项合并临床试验报告标准清单（CONSORT）用于报告临床前体外研究，用于对所选论文的方法学质量进行评分。整体质量被判定为低。结论：尽管SMP具有巨大的潜力和多功能性，但仍不可能得出支持其在临床牙科领域立即就业的循证结论。这是由于设计不力以及本次审查中涉及的研究数量有限，反映了以下事实：必须进行其他研究才能确定在牙科领域使用SMP是否有效。然而，对选定论文和专利的定性分析表明，由于SMP具有可编程的物理特性，它们是牙科领域中很有前途的材料。这些发现表明了进一步开展这一研究的重要性。
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