• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>HPB Surgery >Factors Influencing the Concentrations of the Large Neutral Amino Acids in the Brain and in the CSF of Dogs After Portacaval Anastomosis
【2h】

Factors Influencing the Concentrations of the Large Neutral Amino Acids in the Brain and in the CSF of Dogs After Portacaval Anastomosis

机译：犬脑和脑脊液中大中性氨基酸浓度的影响因素 门腔吻合术

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Portal-systemic shunting of blood is associated with hyperammonemia, an increased glutamine concentration in brain, an altered plasma neutral amino acid pattern, and high levels of several of the large neutral amino acids in brain. Since some of these amino acids are precursors for neurotransmitters and for other potentially neuroactive substances, high CNS levels of these amino acids may contribute to the development of encephalopathy. In order to determine the relative importance of changes in brain glutamine levels and changes in competition among the neutral amino acids for blood-brain transport, we measured the concentrations of the large neutral amino acids in plasma, cisternal cerebrospinal fluid and in brain tissue from various regions of dogs after end-to-side portacaval shunt. Although the changes in CSF amino acid levels correlated partially with altered amino acid plasma competitor ratios, better correlations were observed with the elevation of CSF glutamine. These results suggest a model of blood-brain amino acid transport in which a high level of glutamine in brain extracellular fluid competes with other neutral amino acids for efflux from brain, thus raising brain amino acid levels after portalsystemic shunting
机译：门静脉系统性血液分流与高氨血症，脑中谷氨酰胺浓度升高，血浆中性氨基酸模式改变以及脑中几种大型中性氨基酸含量高有关。由于这些氨基酸中的一些是神经递质和其他潜在神经活性物质的前体，因此这些氨基酸的高中枢神经系统含量可能有助于脑病的发展。为了确定脑中谷氨酰胺水平变化和中性氨基酸之间血脑运输竞争变化的相对重要性，我们测量了血浆，脑脊液和各种组织中脑组织中大中性氨基酸的浓度端到端门腔分流后的犬只区域。尽管脑脊液氨基酸水平的变化与氨基酸血浆竞争者比率的改变部分相关，但观察到脑脊液谷氨酰胺升高的相关性更好。这些结果提示了一种血脑氨基酸转运模型，其中脑细胞外液中的高水平谷氨酰胺与其他中性氨基酸竞争从脑中流出，从而在门静脉系统分流后提高脑氨基酸水平

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号