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首页> 美国卫生研究院文献>Gut >Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease
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Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease

机译：肝硬化患者循环前脑利钠肽（proBNP）和脑利钠肽（BNP）的增加：与心血管功能障碍和疾病严重程度的关系

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>Background and aims: Cardiac dysfunction may be present in patients with cirrhosis. This study was undertaken to relate plasma concentrations of cardiac peptides reflecting early ventricular dysfunction (pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP)) to markers of severity of liver disease, cardiac dysfunction, and hyperdynamic circulation in patients with cirrhosis.>Patients and methods: Circulating levels of proBNP and BNP were determined in 51 cirrhotic patients during a haemodynamic investigation.>Results: Plasma proBNP and BNP were significantly increased in cirrhotic patients (19 and 12 pmol/l, respectively) compared with age matched controls (14 and 6 pmol/l; p<0.02) and healthy subjects (<15 and <5.3 pmol/l; p<0.002). Circulating proBNP and BNP were closely correlated (r = 0.89, p<0.001), and the concentration ratio proBNP/BNP was similar to that of control subjects (1.8 v 2.3; NS). Circulating proBNP and BNP were related to severity of liver disease (Child score, serum albumin, coagulation factors 2, 7, and 10, and hepatic venous pressure gradient) and to markers of cardiac dysfunction (QT interval, heart rate, plasma volume) but not to indicators of the hyperdynamic circulation. Moreover, in multiple regression analysis, proBNP and BNP were also related to arterial carbon dioxide and oxygen tensions. The rate of hepatic disposal of proBNP and BNP was not significantly different in cirrhotic patients and controls.>Conclusion: Elevated circulating levels of proBNP and BNP in patients with cirrhosis most likely reflects increased cardiac ventricular generation of these peptides and thus indicates the presence of cardiac dysfunction, rather than being caused by the hyperdynamic circulatory changes found in these patients.
机译：>背景和目的：肝硬化患者可能存在心脏功能障碍。这项研究的目的是将反映早期心室功能不全的心脏肽（脑钠肽（proBNP）和脑钠肽（BNP））的血浆浓度与肝硬化患者肝病严重程度，心脏功能障碍和高动力循环的标志物联系起来。 。>患者和方法：在血液动力学检查中确定了51位肝硬化患者的proBNP和BNP循环水平。>结果：肝硬化患者的血浆proBNP和BNP显着升高（19和分别为12 pmol / l和12 pmol / l）与年龄匹配的对照组（14和6 pmol / l； p <0.02）和健康受试者（<15和<5.3 pmol / l； p <0.002）进行比较。循环中的proBNP和BNP密切相关（r = 0.89，p <0.001），proBNP / BNP的浓度比与对照组相似（1.8 v 2.3； NS）。循环中的proBNP和BNP与肝病的严重程度（儿童评分，血清白蛋白，凝血因子2、7和10以及肝静脉压梯度）和心脏功能障碍的标志物（QT间期，心率，血浆量）有关，但而不是高动力循环的指标。此外，在多元回归分析中，proBNP和BNP也与动脉二氧化碳和氧气张力有关。肝硬化患者和对照组肝脏中proBNP和BNP的肝处置率无显着差异。>结论：肝硬化患者中proBNP和BNP的循环水平升高很可能反映出这些肽和因此表明存在心脏功能障碍，而不是由这些患者的动态循环改变引起。

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