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Neuroendocrine Neoplasms of the Head and Neck: Some Suggestions for the New WHO Classification of Head and Neck Tumors

机译：头颈部神经内分泌肿瘤：关于WHO头颈部肿瘤新分类的一些建议

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摘要

As knowledge and understanding in pathology evolve, classifications and nomenclature also change to reflect those advances. The 2005 World Health Organization Classification of Head and Neck Tumours was a significant step towards diagnostic standardization of head and neck neuroendocrine carcinomas; however, in the last 10 years there have been new data supporting the recognition of “large cell neuroendocrine carcinoma” as a distinctive high grade carcinoma in the head and neck, a lesion not included in the 2005 Classification. In addition, the terms “middle ear adenoma” and “carcinoid tumor of middle ear” are still widely used to describe a neoplasm that is neither a pure adenoma nor a carcinoid tumor but a lesion with variable mixed exocrine and endocrine differentiation. Largely using the diagnostic criteria of the WHO classification of neuroendocrine carcinomas of the lung, we propose the terms “neuroendocrine carcinoma, grade 1”; “neuroendocrine carcinoma, grade 2”; “neuroendocrine carcinoma, grade 3, large cell type”; and “neuroendocrine carcinoma, grade 3, small cell type” for the classification of neuroendocrine carcinomas of the head and neck in a future WHO classification. In addition, we also proposed the term “mixed epithelial neuroendocrine tumor” of the middle ear as an alternative for “middle ear adenoma” and “carcinoid tumor of the middle ear”.
机译：随着病理学知识和理解的发展，分类和术语也发生变化以反映这些进展。 2005年世界卫生组织《头颈肿瘤分类》是实现头颈神经内分泌癌诊断标准化的重要一步。然而，在过去的十年中，有新的数据支持将“大细胞神经内分泌癌”识别为头颈部的一种特殊的高级别癌，这种病灶未包括在2005分类中。此外，术语“中耳腺瘤”和“中耳类癌”仍被广泛用于描述既不是单纯的腺瘤也不是类癌的肿瘤，而是外分泌和内分泌分化程度不同的病变。我们主要根据WHO肺神经内分泌癌分类的诊断标准，提出“ 1级神经内分泌癌”一词。 “神经内分泌癌，2级”； “神经内分泌癌，3级，大细胞型”；和“神经内分泌癌，3级，小细胞类型”，用于在将来的WHO分类中对头颈部神经内分泌癌进行分类。此外，我们还提出了中耳的“混合上皮神经内分泌肿瘤”一词，以替代“中耳腺瘤”和“中耳类癌”。

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