• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Genetics Research International >Sequence Analysis of Inducible Prophage phIS3501 Integrated into the Haemolysin II Gene of Bacillus thuringiensis var israelensis ATCC35646
【2h】

Sequence Analysis of Inducible Prophage phIS3501 Integrated into the Haemolysin II Gene of Bacillus thuringiensis var israelensis ATCC35646

机译：苏云金芽胞杆菌以色列以色列ATCC35646溶血素II基因诱导型噬菌体phIS3501的序列分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diarrheic food poisoning by bacteria of the Bacillus cereus group is mostly due to several toxins encoded in the genomes. One of them, cytotoxin K, was recently identified as responsible for severe necrotic syndromes. Cytotoxin K is similar to a class of proteins encoded by genes usually annotated as haemolysin II (hlyII) in the majority of genomes of the B. cereus group. The partially sequenced genome of Bacillus thuringiensis var israelensis ATCC35646 contains several potentially induced prophages, one of them integrated into the hlyII gene. We determined the complete sequence and established the genomic organization of this prophage-designated phIS3501. During induction of excision of this prophage with mitomycin C, intact hlyII gene is formed, thus providing to cells a genetic ability to synthesize the active toxin. Therefore, this prophage, upon its excision, can be implicated in the regulation of synthesis of the active toxin and thus in the virulence of bacterial host. A generality of selection for such systems in bacterial pathogens is indicated by the similarity of this genetic arrangement to that of Staphylococcus aureus   β-haemolysin.
机译：蜡状芽孢杆菌属细菌引起的腹泻食物中毒主要归因于基因组中编码的几种毒素。最近发现其中一种是细胞毒素K，可导致严重的坏死综合征。细胞毒素K类似于蜡样芽孢杆菌（B. cereus）组大多数基因组中通常标注为溶血素II（hlyII）的基因编码的一类蛋白质。苏云金芽孢杆菌var ISraelensis ATCC35646的部分测序的基因组包含数种可能诱导的噬菌体，其中之一整合到hlyII基因中。我们确定了完整的序列，并建立了此前噬菌体phIS3501的基因组组织。在用丝裂霉素C诱导该噬菌体切除的过程中，形成完整的hlyII基因，从而为细胞提供了合成活性毒素的遗传能力。因此，该预言一旦切除，可能与活性毒素合成的调节有关，从而与细菌宿主的毒力有关。这种基因安排与金黄色葡萄球菌β-溶血素的相似性表明了细菌病原体中此类系统选择的普遍性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号