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首页> 美国卫生研究院文献>Genetics >A Role for Acp29AB a Predicted Seminal Fluid Lectin in Female Sperm Storage in Drosophila melanogaster
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A Role for Acp29AB a Predicted Seminal Fluid Lectin in Female Sperm Storage in Drosophila melanogaster

机译：Acp29AB一种预测的精液凝集素在果蝇中的女性精子存储中的作用。

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摘要

Females of many animal species store sperm for taxon-specific periods of time, ranging from a few hours to years. Female sperm storage has important reproductive and evolutionary consequences, yet relatively little is known of its molecular basis. Here, we report the isolation of a loss-of-function mutation of the Drosophila melanogaster Acp29AB gene, which encodes a seminal fluid protein that is transferred from males to females during mating. Using this mutant, we show that Acp29AB is required for the normal maintenance of sperm in storage. Consistent with this role, Acp29AB localizes to female sperm storage organs following mating, although it does not appear to associate tightly with sperm. Acp29AB is a predicted lectin, suggesting that sugar–protein interactions may be important for D. melanogaster sperm storage, much as they are in many mammals. Previous association studies have found an effect of Acp29AB genotype on a male's sperm competitive ability; our findings suggest that effects on sperm storage may underlie these differences in sperm competition. Moreover, Acp29AB's effects on sperm storage and sperm competition may explain previously documented evidence for positive selection on the Acp29AB locus.
机译：许多动物物种的雌性会在特定的分类时间段内储存精子，时间从数小时到数年不等。女性精子的储存具有重要的生殖和进化作用，但其分子基础知之甚少。在这里，我们报告果蝇果蝇Acp29AB基因的功能丧失突变的分离，该基因编码在交配过程中从雄性转移到雌性的精液蛋白。使用此突变体，我们表明Acp29AB是正常保存精子所必需的。与此角色一致，Acp29AB在交配后定位于雌性精子存储器官，尽管它似乎与精子没有紧密的联系。 Acp29AB是一种预测的凝集素，表明糖-蛋白质相互作用对于黑腹果蝇的精子储存可能很重要，就像许多哺乳动物中一样。先前的关联研究已经发现Acp29AB基因型对男性精子竞争能力的影响。我们的发现表明，对精子储存的影响可能是精子竞争中这些差异的基础。此外，Acp29AB对精子贮藏和精子竞争的影响可能解释了Acp29AB基因座上阳性选择的先前文献记载。

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