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Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

机译：评估脱靶和脱靶评分算法并将其整合到指南RNA选择工具CRISPOR中

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BackgroundThe success of the CRISPR/Cas9 genome editing technique depends on the choice of the guide RNA sequence, which is facilitated by various websites. Despite the importance and popularity of these algorithms, it is unclear to which extent their predictions are in agreement with actual measurements.

机译：背景技术CRISPR / Cas9基因组编辑技术的成功取决于指导RNA序列的选择，该指导可通过各种网站来实现。尽管这些算法很重要且很受欢迎，但尚不清楚它们的预测在多大程度上与实际测量结果一致。

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期刊名称 Genome Biology
作者
Maximilian Haeussler; Kai Schönig; Hélène Eckert; Alexis Eschstruth; Joffrey Mianné; Jean-Baptiste Renaud; Sylvie Schneider-Maunoury; Alena Shkumatava; Lydia Teboul; Jim Kent; Jean-Stephane Joly; Jean-Paul Concordet;
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年(卷),期 2016(17),-1
年度 2016
页码 148
总页数 12
原文格式 PDF
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中图分类生物学;
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专利

1. Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR [J] . Maximilian Haeussler, Kai Sch?nig, Hélène Eckert, Genome Biology . 2016,第3期

机译：评估脱靶和脱靶评分算法并将其整合到指南RNA选择工具CRISPOR中
2. Selecting guide RNAs with high on-target and low off-target activity using CRISPOR [J] . Haeussler Maximilian, Schoenig Kai, Eckert Helene, Transgenic research . 2016,第2期

机译：使用CRISPOR选择具有高靶向活性和低脱靶活性的指导RNA
3. Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity [J] . Yi Yu, Thomas C. Leete, David A. Born, Nature Communications . 2020,第1期

机译：胞嘧啶基础编辑器，具有最小化的无导体DNA和RNA脱靶事件和高目标活动
4. Laplacian Score and Top Scoring Pair Feature Selection Algorithms [C] . Kavitha K R, Neeradha K, Athira, International Conference on Computing Methodologies and Communication . 2020

机译：拉普拉斯分数和最高得分对特征选择算法
5. Algorithms for efficient process-planning and automated tool sequence selection for 2.5-axis and 3-axis rough milling operations. [D] . D'Souza, Roshan Merwyn. 2003

机译：用于2.5轴和3轴粗铣加工的有效工艺规划和自动刀具顺序选择算法。
6. Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases [O] . Lin Lin, Yong Liu, Fengping Xu, 2018

机译：dCas9甲基转移酶对RNA引导的DNA甲基化的靶点和脱靶特征进行全基因组测定
7. Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR [O] . Maximilian Haeussler, Kai Schönig, Hélène Eckert, 2016

机译：评估脱靶和脱靶评分算法并将其整合到指南RNA选择工具CRISPOR中
8. Probabilistic Algorithms, Integration, and Empirical Evaluation for Disambiguating Multiple Selections in Frustum-Based Pointing [R] . Schmidt, G, Brown, D G, Tomlin, E B, 2006

机译：基于Frustum的指向中多重选择消除歧义的概率算法，积分和实证评估

Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

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