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Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective

机译：从网络角度解读肥胖与各种疾病之间的关系

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摘要

The number of obesity cases is rapidly increasing in developed and developing countries, thereby causing significant health problems worldwide. The pathologic factors of obesity at the molecular level are not fully characterized, although the imbalance between energy intake and consumption is widely recognized as the main reason for fat accumulation. Previous studies reported that obesity can be caused by the dysfunction of genes associated with other diseases, such as myocardial infarction, hence providing new insights into dissecting the pathogenesis of obesity by investigating its associations with other diseases. In this study, we investigated the relationship between obesity and diseases from Online Mendelian Inheritance in Man (OMIM) databases on the protein–protein interaction (PPI) network. The obesity genes and genes of one OMIM disease were mapped onto the network, and the interaction scores between the two gene sets were investigated on the basis of the PPI of individual gene pairs, thereby inferring the relationship between obesity and this disease. Results suggested that diseases related to nutrition and endocrine are the top two diseases that are closely associated with obesity. This finding is consistent with our general knowledge and indicates the reliability of our obtained results. Moreover, we inferred that diseases related to psychiatric factors and bone may also be highly related to obesity because the two diseases followed the diseases related to nutrition and endocrine according to our results. Numerous obesity–disease associations were identified in the literature to confirm the relationships between obesity and the aforementioned four diseases. These new results may help understand the underlying molecular mechanisms of obesity–disease co-occurrence and provide useful insights for disease prevention and intervention.
机译：在发达国家和发展中国家，肥胖病例的数量正在迅速增加，从而在世界范围内引起严重的健康问题。尽管能量摄入和消耗之间的不平衡被广泛认为是脂肪积累的主要原因，但在分子水平上肥胖的病理因素并未得到充分表征。先前的研究报道，肥胖可能是由与其他疾病（如心肌梗塞）相关的基因功能异常引起的，因此，通过研究肥胖与其他疾病的关系，为剖析肥胖的发病机理提供了新的见解。在这项研究中，我们从蛋白质间相互作用（PPI）网络上的在线孟德尔男性遗传（OMIM）数据库中研究了肥胖与疾病之间的关系。将肥胖基因和一种OMIM疾病的基因映射到网络上，并基于单个基因对的PPI研究两个基因组之间的相互作用评分，从而推断肥胖与该疾病之间的关系。结果表明，与营养和内分泌有关的疾病是与肥胖密切相关的两大疾病。这一发现与我们的常识相一致，并表明了我们获得的结果的可靠性。此外，我们推断与精神因素和骨骼有关的疾病也可能与肥胖高度相关，因为根据我们的结果，这两种疾病紧随与营养和内分泌有关的疾病。在文献中鉴定出许多肥胖-疾病关联，以证实肥胖与上述四种疾病之间的关系。这些新结果可能有助于了解肥胖-疾病共存的潜在分子机制，并为疾病预防和干预提供有用的见识。

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