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首页> 美国卫生研究院文献>Genes Development >Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons
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Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons

机译：鼻区表达的新基因影响嗅轴突的生长和促黄体生成激素释放激素（LHRH）神经元的迁移

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Although a variety of cues have been implicated in axonal targeting during embryogenesis and regeneration, the precise mechanisms guiding olfactory axons remain unclear. Appropriate olfactory axon pathfinding is essential for functional chemoreceptive and pheromone receptive systems. Olfactory axon pathfinding is also necessary for establishment of the neuroendocrine LHRH system, cells critical for reproductive function. LHRH cells exhibit neurophilic migration moving from the nasal region along olfactory axons into the brain. Factors involved in the migration of these neuroendocrine cells are as yet unresolved. We report identification of a novel factor termed nasal embryonic LHRH factor (NELF) that was discovered in a differential screen of migrating versus nonmigrating primary LHRH neurons. NELF is expressed in PNS and CNS tissues during embryonic development, including olfactory sensory cells and LHRH cells. NELF antisense experiments indicate that a reduction in NELF expression decreases olfactory axon outgrowth and the number of LHRH neurons that migrate out of the nasal tissue. These results demonstrate that NELF plays a role as a common guidance molecule for olfactory axon projections and subsequently, either directly or indirectly, in the neurophilic migration of LHRH cells.
机译：尽管在胚胎发生和再生过程中涉及到各种轴突靶向的线索，但指导嗅觉轴突的确切机制仍不清楚。适当的嗅觉轴突寻路对于功能性化学感受器和信息素接收系统至关重要。嗅觉轴突寻路对于建立神经内分泌LHRH系统（对生殖功能至关重要的细胞）也是必要的。 LHRH细胞表现出嗜神经性迁移，从嗅觉轴突从鼻部区域进入大脑。这些神经内分泌细胞迁移所涉及的因素尚未解决。我们报告鉴定的新型因子称为鼻胚LHRH因子（NELF）的发现是在迁移与未迁移的主要LHRH神经元的差异筛选中发现的。 NELF在胚胎发育过程中在PNS和CNS组织中表达，包括嗅觉感觉细胞和LHRH细胞。 NELF反义实验表明，NELF表达的减少会减少嗅轴突的生长，并减少从鼻组织中迁移出来的LHRH神经元的数量。这些结果表明，NELF充当嗅轴突投射的共同指导分子，随后直接或间接地参与LHRH细胞的嗜神经性迁移。

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