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Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities

机译：葡萄糖6磷酸酶脱氢酶（G6PD）和神经退行性疾病：定位诊断和治疗机会

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Glucose 6 phosphate dehydrogenase (G6PD) is a key and rate limiting enzyme in the pentose phosphate pathway (PPP). The physiological significance of enzyme is providing reduced energy to specific cells like erythrocyte by maintaining co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). There are preponderance research findings that demonstrate the enzyme (G6PD) role in the energy balance, and it is associated with blood-related diseases and disorders, primarily the anemia resulted from G6PD deficiency. The X-linked genetic deficiency of G6PD and associated non-immune hemolytic anemia have been studied widely across the globe. Recent advancement in biology, more precisely neuroscience has revealed that G6PD is centrally involved in many neurological and neurodegenerative disorders. The neuroprotective role of the enzyme (G6PD) has also been established, as well as the potential of G6PD in oxidative damage and the Reactive Oxygen Species (ROS) produced in cerebral ischemia. Though G6PD deficiency remains a global health issue, however, a paradigm shift in research focusing the potential of the enzyme in neurological and neurodegenerative disorders will surely open a new avenue in diagnostics and enzyme therapeutics. Here, in this study, more emphasis was made on exploring the role of G6PD in neurological and inflammatory disorders as well as non-immune hemolytic anemia, thus providing diagnostic and therapeutic opportunities.
机译：葡萄糖6磷酸脱氢酶（G6PD）是戊糖磷酸途径（PPP）中的关键和限速酶。酶的生理学意义是通过维持辅酶烟酰胺腺嘌呤二核苷酸磷酸（NADPH）来减少特定细胞（如红细胞）的能量。有大量的研究发现表明该酶（G6PD）在能量平衡中的作用，并且与血液相关的疾病和失调有关，主要是由G6PD缺乏引起的贫血。 X连锁的G6PD遗传缺陷和相关的非免疫溶血性贫血已在全球范围内得到广泛研究。生物学（更确切地说是神经科学）的最新进展表明，G6PD参与了许多神经系统疾病和神经退行性疾病。还已经确定了该酶（G6PD）的神经保护作用，以及G6PD在脑缺血中产生的氧化损伤和活性氧（ROS）的潜力。尽管G6PD缺乏症仍然是一个全球性的健康问题，但是，针对酶在神经系统疾病和神经退行性疾病中的潜力进行研究的范式转变必将为诊断学和酶疗法开辟一条新途径。在此，在这项研究中，更多地强调了探索G6PD在神经系统疾病，炎性疾病以及非免疫性溶血性贫血中的作用，从而提供了诊断和治疗的机会。

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