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首页> 外文会议>International Conference on Biological Science >Screening of glucose-6-phosphate dehydrogenase (G6PD) deficiency in two high endemic malaria populations, West Papua province and North Moluccas
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Screening of glucose-6-phosphate dehydrogenase (G6PD) deficiency in two high endemic malaria populations, West Papua province and North Moluccas

机译：筛选葡萄糖-6-磷酸盐脱氢酶（G6PD）缺乏两种高处理疟疾群体，西巴布亚省和北莫尔卡斯

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a X-chromosomally transmitted disorder of the erythrocyte that affects 400 million people worldwide. In Indonesia, this affect become the burden in malaria treatment since primaquine, one of main therapy applied in Indonesia which causes a mild to severe acute haemolytic for G6PD deficiency persons. This study is on-going study to observe the prevalence of G6PD phenotypically and genetically. Aim of this study is to describe the prevalent of G6PD in two high endemic malaria deficiency area Papua and North Moluccas. Our total sampled was 179 residents consist of 82 samples from West Papua and 97 from North Mollucas. In the province we sampled from 3 separates districts. Analysis Screening of G6PD deficiency phenotypically was done using G6PD Care A Start G6PD rapid test using 3 μl venosus blood. The blood was dropped to the rapid diagnostic kit and read after 10 minutes but not more than 30 minutes. The purple color is interpreted as a normal but colorless is G6PD deficiency. Result show that phenotypically, 4.8 % of samples from West Papua are G6PD deficiency and 3% of North Moluccas samples are G6PD deficiency. Since the study area is malaria endemic area that becomes a warning to administered primaquine as a malaria theraphy to an individu with G6PD deficiency.
机译：葡萄糖-6-磷酸盐脱氢酶（G6PD）缺乏是X-染色体的红细胞疾病，其红细胞影响全世界4亿人。在印度尼西亚，这一影响成为自初步治疗后疟疾治疗的负担，其中一个主要疗法应用于印度尼西亚的主要疗法，这导致对G6PD缺乏人的严重急性血液溶解剂。本研究正在逐步研究，以观察到G6PD的普遍性和遗传学。本研究的目的是描述两种高处理疟疾缺陷面积巴布亚和北莫拉卡的G6PD普遍存在。我们的分样是179名居民，包括来自西巴布拉的82个样本，来自北方Mollucas的97个。在全省，我们从3个分开的地区取样。通过使用G6PD护理，通过3μLvenosus血液开始G6PD缺陷的分析筛选G6PD缺乏表型。血液滴到快速诊断试剂盒中，并在10分钟后读数，但不超过30分钟。紫色被解释为正常但无色是G6PD缺陷。结果表明，从西巴布亚的4.8％的样品中的表型是G6PD缺乏，3％的北Moluccas样本是G6PD缺乏。由于研究区域是疟疾流行区域，其成为向疟疾给予疟原虫的警告，因为对具有G6PD缺乏的个体的疟疾。

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