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GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD)-MODULATING AGENTS AND METHODS OF TREATING G6PD DEFICIENCY
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD)-MODULATING AGENTS AND METHODS OF TREATING G6PD DEFICIENCY
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机译:葡萄糖6-磷酸脱氢酶(G6PD)调节剂和治疗G6PD缺乏症的方法
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摘要
Aspects of the present disclosure include G6PD-modulating agents and methods for modulating a glucose-6-phosphate dehydrogenase (G6PD) in a sample using such agents. A G6PD-modulating agent can be dimeric and include two terminal carbocyclic or heterocyclic groups connected via a linker. In some instances, the agent includes a diamino-containing linker. In certain cases, the agent includes two amino substituents. Also provided are methods for treating a subject for a G6PD deficiency-associated condition, that include administering to a subject an effective amount of a G6PD-modulating agent to selectively activate a mutant G6PD and treat the subject. Kits and compositions for practicing the subject methods are also provided.
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