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首页> 美国卫生研究院文献>Gastroenterology Research >Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies
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Non-invasive Adenocarcinoma of the Vermiform Appendix: Incidence and Report of Four Cases among 512 Appendectomies

机译：Ver状无创性腺癌附录：512例附录中4例的发病率和报告

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摘要

Tumors of the vermiform appendix are relatively rare. More than 50% of appendiceal tumors are carcinoid tumors. The author reviewed 512 consecutive pathological specimens of appendectomies in last ten years in our pathology laboratory in search for appendiceal tumors. As the results, 4 cases (incidence: 0.8%) of non-invasive adenocarcinoma were found. No other tumors including carcinoid tumors were recognized. The age of the 4 patients with adenocarcinoma was 48, 39, 84 and 86 years, respectively. Male to female ratio was 3:1. The clinical diagnoses were acute appendicitis in 2 cases and suspected malignancy in 2 cases. The post-operative outcome was good without metastasis, recurrence, and pseudomyxoma peritonei. Pathologically, all the 4 tumors were non-invasive adenocarcinomas: 2 cases were flat type adenocarcinoma, 1 case was papillary adenocarcinoma, and 1 case was mucinous adenocarcinoma. Immunohistochemically, expression of p53 protein was observed in all the 4 cases, and Ki-67 labeling ranged from 40% to 90%. The results suggest that incidence of appendiceal adenocarcinoma was 0.8% of all appendectomies, and that non-invasive adenocarcinoma of the appendix shows variable morphologies, and that postoperative clinical outcome of non-invasive appendiceal tumor is good.
机译：ver状阑尾的肿瘤相对少见。阑尾肿瘤的50％以上是类癌。作者在我们的病理实验室中回顾了近十年来的512个连续的阑尾切除术病理标本，以寻找阑尾肿瘤。结果，发现4例（发生率：0.8％）无创性腺癌。没有其他肿瘤包括类癌被识别。 4名腺癌患者的年龄分别为48、39、84和86岁。男女比例为3：1。临床诊断为急性阑尾炎2例，疑似恶性肿瘤2例。术后预后良好，无转移，复发和腹膜假性黏液瘤。病理上，全部4个肿瘤均为非浸润性腺癌：扁平型腺癌2例，乳头状腺癌1例，粘液性腺癌1例。免疫组织化学观察，在所有4例病例中均观察到p53蛋白的表达，且Ki-67标记的范围为40％至90％。结果表明，阑尾腺癌的发生率为所有阑尾切除术的0.8％，并且阑尾的非侵入性腺癌表现出多种形态，并且非侵入性阑尾肿瘤的术后临床预后良好。

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