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首页> 美国卫生研究院文献>Gels >On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery
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On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery

机译：交变磁场从磁铁矿纳米颗粒交联的多糖水凝胶中释放药物的机理研究：以DOXO传递为例

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The chemical, biological and physical properties of carboxymethylcellulose (CMC) hydrogels with silanized magnetite (Fe3O4) nanoparticles (NPs) as cross-linker were investigated and compared with the analogous hydrogel obtained by using 1,3-diaminopropane (DAP) as cross-linker. The magnetic hydrogel was characterized from the chemical point of view by FT-IR, whereas the morphology of the hydrogel was investigated by FESEM and STEM. The water uptake and rheological measurements reveal how much the swelling and mechanical properties change when CMC is cross-linked with silanized magnetite NPs instead of with DAP. As far as the biological properties, the hybrid hydrogel neither exerts any adverse effect nor any alteration on the cells. The magnetic hydrogels show magnetic hysteresis at 2.5 K as well as at 300 K. Magnetic measurements show that the saturation magnetization, remanent magnetization and coercive field of the NPs are not influenced significantly by the silanization treatment. The magnetic hydrogel was tested as controlled drug delivery system. The release of DOXO from the hydrogel is significantly enhanced by exposing it to an alternating magnetic field. Under our experimental conditions (2 mT and 40 kHz), no temperature increase of the hydrogel was measured, testifying that the mechanism for the enhancement of drug release under the AMF involves the twisting of the polymeric chains. A static magnetic field (0.5 T) does not influence the drug release from the hydrogel, compared with that without magnetic field.
机译：研究了以硅烷化磁铁矿（Fe3O4）纳米颗粒（NPs）为交联剂的羧甲基纤维素（CMC）水凝胶的化学，生物学和物理性质，并与以1,3-二氨基丙烷（DAP）为交联剂得到的类似水凝胶进行了比较。 。磁性水凝胶通过化学性质的红外光谱进行了表征，而水凝胶的形态则通过FESEM和STEM进行了研究。吸水率和流变学测量表明，当CMC与硅烷化磁铁矿NP而不是DAP交联时，溶胀和机械性能发生了多少变化。就生物学特性而言，杂化水凝胶既不会对细胞产生任何不利影响也不会造成任何改变。磁性水凝胶在2.5 K和300 K处显示磁滞。磁性测量表明，硅烷化处理不会显着影响NP的饱和磁化强度，剩余磁化强度和矫顽场。测试了磁性水凝胶作为药物控制系统。通过将DOXO暴露在交变磁场中，可以显着增强DOXO从水凝胶中的释放。在我们的实验条件下（2 mT和40 kHz），没有测量到水凝胶的温度升高，证明在AMF下提高药物释放的机理涉及聚合物链的扭曲。与没有磁场的情况相比，静磁场（0.5 T）不会影响药物从水凝胶中的释放。

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