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首页> 美国卫生研究院文献>Frontiers in Systems Neuroscience >Is Social Phobia a Mis-Communication Disorder? Brain Functional Connectivity during Face Perception Differs between Patients with Social Phobia and Healthy Control Subjects
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Is Social Phobia a Mis-Communication Disorder? Brain Functional Connectivity during Face Perception Differs between Patients with Social Phobia and Healthy Control Subjects

机译：社交恐惧症是误传疾病吗？社交恐惧症患者与健康对照组之间的面部知觉过程中的大脑功能连接有所不同

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Recently, a differential recruitment of brain areas throughout the distributed neural system for face perception has been found in social phobic patients as compared to healthy control subjects. These functional abnormalities in social phobic patients extend beyond emotion-related brain areas, such as the amygdala, to include cortical networks that modulate attention and process other facial features, and they are also associated with an alteration of the task-related activation/deactivation trade-off. Functional connectivity is becoming a powerful tool to examine how components of large-scale distributed neural systems are coupled together while performing a specific function. This study was designed to determine whether functional connectivity networks among brain regions within the distributed system for face perception also would differ between social phobic patients and healthy controls. Data were obtained from eight social phobic patients and seven healthy controls by using functional magnetic resonance imaging. Our findings indicated that social phobic patients and healthy controls have different patterns of functional connectivity across brain regions within both the core and the extended systems for face perception and the default mode network. To our knowledge, this is the first study that shows that functional connectivity during brain response to socially relevant stimuli differs between social phobic patients and healthy controls. These results expand our previous findings and indicate that brain functional changes in social phobic patients are not restricted to a single specific brain structure, but rather involve a mis-communication among different sensory and emotional processing brain areas.
机译：最近，在社交恐惧症患者中，与健康对照组相比，发现了整个分布式神经系统中用于面部感知的大脑区域的差异募集。社交恐惧症患者的这些功能异常超出了与情感相关的大脑区域（如杏仁核）的范围，包括可调节注意力并处理其他面部特征的皮质网络，并且它们还与任务相关的激活/停用交易有关-关。功能连接性正在成为检查大型分布式神经系统的组件如何在执行特定功能时耦合在一起的强大工具。这项研究旨在确定在社交恐惧症患者和健康对照者之间，用于面部感知的分布式系统内大脑区域之间的功能连接网络是否也会有所不同。通过使用功能磁共振成像从八名社交恐惧症患者和七名健康对照中获得数据。我们的研究结果表明，社交恐惧症患者和健康对照者在面部感知和默认模式网络的核心系统和扩展系统内的大脑区域中具有不同的功能连接模式。据我们所知，这是第一项研究，表明社交恐惧症患者和健康对照者在大脑对社交相关刺激的反应过程中的功能连通性有所不同。这些结果扩展了我们先前的发现，并表明社交恐惧症患者的脑功能变化不仅限于单个特定的大脑结构，而是涉及不同感觉和情感处理大脑区域之间的错误沟通。

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