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首页> 美国卫生研究院文献>Frontiers in Veterinary Science >Diagnostic Performance of Clinicopathological Analytes in Otostrongylus circumlitis-Infected Rehabilitating Juvenile Northern Elephant Seals (Mirounga angustirostris)
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Diagnostic Performance of Clinicopathological Analytes in Otostrongylus circumlitis-Infected Rehabilitating Juvenile Northern Elephant Seals (Mirounga angustirostris)

机译：临床病理分析物在耳圆虫感染的康复北象海豹（Mirounga angustirostris）中的临床病理分析性能

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The nematode lungworm, Otostrongylus circumlitis (OC), is a significant cause of northern elephant seal (NES; Mirounga angustirostris) mortality at The Marine Mammal Center (TMMC, Sausalito, CA). The current lack of specific antemortem diagnostic tests for pre-patent OC infection in NES makes diagnosis, proper treatment, and assessment of efficacy of medications challenging. Severe inflammation and disseminated intravascular coagulation (DIC) develop rapidly and are difficult to treat once clinical signs develop. Certain blood inflammatory and hemostasis biomarkers for early diagnosis have recently been investigated. The objective of this study was to investigate the diagnostic performance of complete blood count, serum chemistry, acute phase proteins, protein electrophoresis, and coagulation parameters for diagnosis of OC clinical infection in NES. Samples from NES with OC infection confirmed by gross pathology with blood collected antemortem during clinical disease (n = 9) and NES initially admitted for malnutrition and sampled shortly before release after successful rehabilitation (n = 20) were included in the study. Using Receiver operator characteristic (ROC) curve analysis, the diagnostic performances (area under the curve [AUC]) of albumin (0.994), albumin:globulin ratio (0.983), serum amyloid A (0.972), activated partial thromboplastin time (0.936), total bilirubin (0.975), and gamma-glutamyl transferase (0.939) were high (AUC > 0.9). These results confirm systemic inflammation and DIC, and support previously reported clinical and gross pathological findings in NES infected with OC. In addition to AUC values, this study produced cut-off points, sensitivity, specificity, confidence intervals, and predictive values for analytes with high diagnostic performance. This data will be useful in the diagnosis and clinical management of OC-infected NES and will aid in assessment of treatment efficacy.
机译：线虫肺圆虫（Otostrongylus circumlitis，OC）是造成海洋哺乳动物中心（TMMC，Sausalito，CA）北部象海豹（NES； Mirounga angustirostris）死亡的重要原因。目前尚无针对NES专利前OC感染的特定前验诊断测试，这使得诊断，适当治疗和药物疗效评估具有挑战性。严重炎症和弥散性血管内凝血（DIC）迅速发展，一旦临床体征发展就很难治疗。最近已经研究了某些用于早期诊断的血液炎症和止血生物标志物。这项研究的目的是调查全血细胞计数，血清化学，急性期蛋白，蛋白电泳和凝血参数对NES OC临床感染的诊断性能。通过总体病理证实的NES患有OC感染的NES样本，在临床疾病期间收集了死前血液（n = 9），并且最初被接纳为营养不良并在成功康复后不久释放的NES样本（n = 20）被包括在研究中。使用接收器操作员特征（ROC）曲线分析，白蛋白（0.994），白蛋白：球蛋白比（0.983），血清淀粉样蛋白A（0.972），活化的部分凝血活酶时间（0.936）的诊断性能（曲线下面积[AUC]） ，总胆红素（0.975）和γ-谷氨酰转移酶（0.939）较高（AUC> 0.9）。这些结果证实了全身炎症和DIC，并支持先前报道的OC感染NES的临床和总体病理发现。除了AUC值，这项研究还为具有较高诊断性能的分析物提供了临界点，灵敏度，特异性，置信区间和预测值。该数据将对OC感染的NES的诊断和临床管理有用，并有助于评估治疗效果。

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