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首页> 美国卫生研究院文献>Frontiers in Neuroanatomy >Flexible and Stable Value Coding Areas in Caudate Head and Tail Receive Anatomically Distinct Cortical and Subcortical Inputs
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Flexible and Stable Value Coding Areas in Caudate Head and Tail Receive Anatomically Distinct Cortical and Subcortical Inputs

机译：尾状头和尾中灵活而稳定的价值编码区域接收解剖学上不同的皮层和皮层下输入

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Anatomically distinct areas within the basal ganglia encode flexible- and stable-value memories for visual objects (Hikosaka et al., ), but an important question remains: do they receive inputs from the same or different brain areas or neurons? To answer this question, we first located flexible and stable value-coding areas in the caudate head (CDh) and caudate tail (CDt) of two rhesus macaque monkeys, and then injected different retrograde tracers into these areas of each monkey. We found that CDh and CDt received different inputs from several cortical and subcortical areas including temporal cortex, prefrontal cortex, cingulate cortex, amygdala, claustrum and thalamus. Superior temporal cortex and inferior temporal cortex projected to both CDh and CDt, with more CDt-projecting than CDh-projecting neurons. In superior temporal cortex and dorsal inferior temporal cortex, layers 3 and 5 projected to CDh while layers 3 and 6 projected to CDt. Prefrontal and cingulate cortex projected mostly to CDh bilaterally, less to CDt unilaterally. A cluster of neurons in the basolateral amygdala projected to CDt. Rostral-dorsal claustrum projected to CDh while caudal-ventral claustrum projected to CDt. Within the thalamus, different nuclei projected to either CDh or CDt. The medial centromedian nucleus and lateral parafascicular nucleus projected to CDt while the medial parafascicular nucleus projected to CDh. The inferior pulvinar and lateral dorsal nuclei projected to CDt. The ventral anterior and medial dorsal nuclei projected to CDh. We found little evidence of neurons projecting to both CDh and CDt across the brain. These data suggest that CDh and CDt can control separate functions using anatomically separate circuits. Understanding the roles of these striatal projections will be important for understanding how value memories are created and stored.
机译：基底神经节在解剖学上不同的区域编码视觉对象的灵活和稳定值的记忆（Hikosaka等，），但是仍然存在一个重要的问题：它们是否从相同或不同的大脑区域或神经元接收输入？为了回答这个问题，我们首先在两只猕猴的尾状头（CDh）和尾状尾（CDt）中定位了灵活而稳定的值编码区域，然后将不同的逆行示踪剂注入到每只猴子的这些区域中。我们发现CDh和CDt从几个皮质和皮质下区域接受了不同的输入，包括颞叶皮质，前额叶皮质，扣带状皮质，杏仁核，锁骨和丘脑。颞上皮层和下颞皮层都投射到CDh和CDt上，而投射CDt的比投射CDh的神经元要多。在颞上皮和背下颞皮中，第3和第5层投射到CDh，而第3和第6层投射到CDt。前额叶和扣带回皮层主要向两侧投射到CDh，单边投射到CDt。基底外侧杏仁核中的神经元簇投射至CDt。延髓－背腹锁骨投射到CDt，而尾－腹锁骨投射到CDt。在丘脑内，不同的核投射到CDh或CDt。内侧着丝粒体核和外侧束旁核突出至CDt，而内侧束旁核突出至CDh。下颌骨和外侧背核投射至CDt。腹前部和内侧背核投射至CDh。我们发现几乎没有证据表明神经元会跨大脑投射到CDh和CDt上。这些数据表明CDh和CDt可以使用解剖上分离的电路来控制分离的功能。了解这些纹状体投射的作用对于了解如何创建和存储价值记忆至关重要。

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