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首页> 美国卫生研究院文献>Frontiers in Aging Neuroscience >A Clinical Research Study of Cognitive Dysfunction and Affective Impairment after Isolated Brainstem Stroke
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A Clinical Research Study of Cognitive Dysfunction and Affective Impairment after Isolated Brainstem Stroke

机译：孤立性脑干卒中后认知功能障碍和情感障碍的临床研究

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Although the function of the cerebellum in neurocognition has been well-documented, the similar role of the brainstem has yet to be fully elucidated. This clinical research study aimed to combine data relating to neuropsychological assessments and P300 to explore cognitive dysfunction and affective impairment following brainstem stroke. Thirty-four patients with isolated brainstem stroke and twenty-six healthy controls were recruited; for each patient, we collated data pertaining to the P300, Addenbrooke's Cognitive Examination III (ACE-III), Montreal Cognitive Assessment Chinese version (MoCA), trail-making test (TMT), Symbol Digit Modalities Test (SDMT), Wechsler Adult Intelligence Scale-Digit Spans (DS), Stroop test, Self Rating Depression Scale (SDS), and Self Rating Anxiety Scale (SAS). Significance was analyzed using an independent T-test or the Mann-Whitney U-test. Correlation was analyzed using Pearson's correlation analysis or Spearman's correlation analysis. Collectively, data revealed that brainstem stroke caused mild cognitive impairment (MCI), and that visuospatial, attention, linguistic, and emotional disturbances may occur after isolated brainstem stroke. Cognitive decline was linked to P300 latency, ACE-III, and MoCA; P300 latency was correlated with ACE-III. Patients with right brainstem lesions were more likely to suffer memory decline. The present study provides initial data relating to the role of the brainstem in neurocognition, and will be useful for further understanding of vascular cognitive and affective impairment.
机译：尽管小脑在神经认知中的功能已有充分文献记载，但脑干的类似作用尚待充分阐明。这项临床研究旨在结合与神经心理学评估和P300相关的数据，探讨脑干卒中后的认知功能障碍和情感障碍。招募了34例脑干卒中患者和26例健康对照者。对于每位患者，我们整理了有关P300，Addenbrooke认知考试III（ACE-III），蒙特利尔认知评估中文版（MoCA），追踪测试（TMT），符号数字模态测试（SDMT），韦氏成人智力的数据量表数字跨度（DS），Stroop测试，自评抑郁量表（SDS）和自评焦虑量表（SAS）。使用独立的T检验或Mann-Whitney U检验分析显着性。相关性使用Pearson相关分析或Spearman相关分析进行分析。总体而言，数据显示脑干中风会引起轻度认知障碍（MCI），孤立的脑干中风后可能会出现视觉空间，注意力，语言和情感障碍。认知能力下降与P300潜伏期，ACE-III和MoCA有关； P300潜伏期与ACE-III相关。右脑干病变的患者更容易出现记忆力减退。本研究提供有关脑干在神经认知中的作用的初步数据，将有助于进一步了解血管性认知和情感障碍。

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