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首页> 美国卫生研究院文献>Frontiers in Endocrinology >Mini Nutritional Assessment Scores Indicate Higher Risk for Prospective Mortality and Contrasting Correlation With Age-Related Epigenetic Biomarkers
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Mini Nutritional Assessment Scores Indicate Higher Risk for Prospective Mortality and Contrasting Correlation With Age-Related Epigenetic Biomarkers

机译：迷你营养评估评分表明预期死亡率以及与年龄相关的表观遗传标记之间的相关性较高的风险

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The plasticity of the individual epigenetic landscape that goes to countless rearrangements throughout life is closely the reflection of environmental factors such as chemical exposure, socio-economic status and nutrient intakes both early and late in life. The Mini Nutritional Assessment (MNA) is a well-validated tool for assessing malnutrition in old people. It includes 6 (MNA-SF) or 18 (MNA-LF) self-reported questions derived from general, anthropometric, dietary, and self- assessment. We evaluated the association between the nutritional status, as measured by MNA, and methylation biomarkers we previously demonstrated to be associated with chronological and biological age in human. We found that malnutrition is positively correlated with DNA methylation status at the global level, in line with our previous reports. On the contrary, most of the sites located within specific genes, which were previously reported to be correlated with chronological and biological aging, showed to be not affected by malnutrition, or even to have correlations with malnutrition opposite to those previously reported with frailty. These results may suggest that malnutrition is among the first effects of disability and other age- related problems and a generalized non-specific epigenetic remodeling may be the initial response of the organism. By contrast, the fine remodeling of specific genomic sites is scarcely affected by malnutrition and may respond to a more complex interaction of different factors. Therefore, although malnutrition in the elderly is certainly a risk factor for survival, this is partially independent of the aging process of the organism which leads to the methylation remodeling previously described to measure chronological and biological aging.
机译：整个生命过程中无数次重新排列的各个表观遗传景观的可塑性与环境因素密切相关，例如化学暴露，社会经济状况以及生命早期和晚期的营养摄入。迷你营养评估（MNA）是用于评估老年人营养不良状况的有效工具。它包括从一般，人体测量，饮食和自我评估中得出的6个（MNA-SF）或18个（MNA-LF）自我报告的问题。我们评估了营养状况（通过MNA衡量）与甲基化生物标志物之间的关联，而甲基化生物标志物先前已证明与人类的年龄和生物年龄相关。根据我们先前的报道，我们发现营养不良与全球范围内的DNA甲基化状态呈正相关。相反，以前被报道与时间和生物衰老相关的位于特定基因内的大多数位点，并未受到营养不良的影响，甚至与营养不良相关，与先前报道的脆弱相关。这些结果可能表明营养不良是残疾和其他与年龄有关的问题的首要影响之一，普遍的非特异性表观遗传重塑可能是有机体的最初反应。相比之下，营养不良几乎不会影响特定基因组位点的精细重塑，并且可能会对不同因素之间更复杂的相互作用做出反应。因此，尽管老年人营养不良无疑是生存的危险因素，但这部分独立于生物体的衰老过程，该过程导致了先前所述的甲基化重塑，用于测量时间和生物衰老。

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