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首页> 美国卫生研究院文献>Frontiers in Cellular and Infection Microbiology >Whole genome sequencing and analysis reveal insights into the genetic structure diversity and evolutionary relatedness of luxI and luxR homologs in bacteria belonging to the Sphingomonadaceae family
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Whole genome sequencing and analysis reveal insights into the genetic structure diversity and evolutionary relatedness of luxI and luxR homologs in bacteria belonging to the Sphingomonadaceae family

机译：全基因组测序和分析揭示了对Sphingomonadaceae家族细菌中luxI和luxR同源物的遗传结构多样性和进化相关性的见解

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Here we report the draft genomes and annotation of four N-acyl homoserine lactone (AHL)-producing members from the family Sphingomonadaceae. Comparative genomic analyses of 62 Sphingomonadaceae genomes were performed to gain insights into the distribution of the canonical luxI/R-type quorum sensing (QS) network within this family. Forty genomes contained at least one luxR homolog while the genome of Sphingobium yanoikuyae B1 contained seven Open Reading Frames (ORFs) that have significant homology to that of luxR. Thirty-three genomes contained at least one luxI homolog while the genomes of Sphingobium sp. SYK6, Sphingobium japonicum, and Sphingobium lactosutens contained four luxI. Using phylogenetic analysis, the sphingomonad LuxR homologs formed five distinct clades with two minor clades located near the plant associated bacteria (PAB) LuxR solo clade. This work for the first time shows that 13 Sphingobium and one Sphingomonas genome(s) contain three convergently oriented genes composed of two tandem luxR genes proximal to one luxI (luxR-luxR-luxI). Interestingly, luxI solos were identified in two Sphingobium species and may represent species that contribute to AHL-based QS system by contributing AHL molecules but are unable to perceive AHLs as signals. This work provides the most comprehensive description of the luxI/R circuitry and genome-based taxonomical description of the available sphingomonad genomes to date indicating that the presence of luxR solos and luxI solos are not an uncommon feature in members of the Sphingomonadaceae family.
机译：在这里我们报告了Sphingomonadaceae家族的四个N-酰基高丝氨酸内酯（AHL）生产成员的基因组草案和注释。进行了62个Sphingomonadaceae基因组的比较基因组分析，以深入了解该家族中规范luxI / R型群体感应（QS）网络的分布。 40个基因组至少包含一个luxR同源物，而Sphingobium yanoikuyae B1的基因组包含七个与luxR具有显着同源性的开放阅读框（ORF）。 33个基因组包含至少一个luxI同源物，而鞘氨醇单胞菌（Sphingobium sp。） SYK6，日本鞘氨醇单胞菌和乳糖鞘氨醇单胞菌含有四个luxI。使用系统发育分析，鞘氨醇LuxR同源物形成了五个不同的进化枝，其中两个较小的进化枝位于植物相关细菌（PAB）LuxR单一进化枝附近。这项工作首次表明，13个鞘氨醇单胞菌和一个鞘氨醇单胞菌基因组包含3个收敛取向的基因，该基因由两个串联在一起的luxR基因组成，它们邻近一个luxI（ luxR-luxR-luxI ）。有趣的是， luxI 个体在两个 Sphingobium 物种中被发现，可能代表通过贡献AHL分子而对基于AHL的QS系统做出贡献的物种，但无法将AHL视为信号。这项工作提供了 luxI / R 电路的最全面描述，以及迄今为止可用的鞘氨醇单胞菌基因组的基于基因组的分类学描述，表明存在 luxR 独奏和 luxI 独奏在 Sphingomonadaceae 家族的成员中并不罕见。

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