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首页> 美国卫生研究院文献>Frontiers in Behavioral Neuroscience >Distinctive Roles of 5-aza-2′-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats
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Distinctive Roles of 5-aza-2′-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats

机译：5-氮杂-2-脱氧胞苷在大鼠前颗粒状小岛和基底外侧杏仁核中在吗啡相关的厌恶记忆重建中的独特作用

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5-aza-2′-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the morphine-naloxone induced conditioned place aversion (CPA) model in rats, we injected 5-aza into agranular insular (AI), granular insular (GI), basolateral amygdala (BLA) and central amygdala (CeA) immediately after the memory retrieval and tested the behavioral consequences at 24 h, 7 and 14 days after retrieval test. We found that 5-aza injection into AI disrupted the reconsolidation of morphine-associated withdrawal memory, but 5-aza injection into GI had no impact on the reconsolidation. Meanwhile, 5-aza injection into BLA but not CeA attenuated the withdrawal memory trace 14 days later. However, 5-aza administration to rats, in the absence of memory reactivation, had no effect on morphine-associated withdrawal memory. These findings suggest that 5-aza interferes with the reconsolidation of opiate withdrawal memory, and the roles of insular and amygdala in reconsolidation are distinctive.
机译：DNA甲基转移酶（DNMT）的抑制剂5-氮杂2'-脱氧胞苷（5-氮杂）与厌恶记忆和涉及情绪处理的大脑区域的功能有关。然而，人们对5-氮杂在鸦片戒断记忆重建中的作用了解甚少。在本研究中，使用吗啡-纳洛酮诱导的大鼠条件性位置厌恶（CPA）模型，将5-氮杂唑注射入无颗粒岛（AI），颗粒岛（GI），基底外侧杏仁核（BLA）和中央杏仁核（CeA）记忆检索后立即进行，并在检索测试后24 h，7和14天测试行为后果。我们发现，向AI注射5氮杂会破坏吗啡相关的戒断记忆的再巩固，但向GI注射5氮杂对再巩固没有影响。同时，向BLA中注入5-氮杂而不是CeA可以减弱14天后的戒断记忆曲线。然而，在没有记忆再激活的情况下，对大鼠进行5-氮杂给予对吗啡相关的戒断记忆没有影响。这些发现表明5-氮杂干扰阿片戒断记忆的再巩固，并且岛突和杏仁核在再巩固中的作用是独特的。

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