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首页> 美国卫生研究院文献>Frontiers in Behavioral Neuroscience >Decoupling Actions from Consequences: Dorsal Hippocampal Lesions Facilitate Instrumental Performance but Impair Behavioral Flexibility in Rats
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Decoupling Actions from Consequences: Dorsal Hippocampal Lesions Facilitate Instrumental Performance but Impair Behavioral Flexibility in Rats

机译：从后果中解耦作用：海马背部病变促进器物性能但损害大鼠的行为灵活性

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The present study is part of a series of experiments, where we analyze why and how damage of the rat’s dorsal hippocampus (dHC) can enhance performance in a sequential reaction time task (SRTT). In this task, sequences of distinct visual stimulus presentations are food-rewarded in a fixed-ratio-13-schedule. Our previous study (Busse and Schwarting, ) had shown that rats with lesions of the dHC show substantially shorter session times and post-reinforcement pauses (PRPs) than controls, which allows for more practice when daily training is kept constant. Since sequential behavior is based on instrumental performance, a sequential benefit might be secondary to that. In order to test this hypothesis in the present study, we performed two experiments, where pseudorandom rather than sequential stimulus presentation was used in rats with excitotoxic dorsal hippocampal lesions. Again, we found enhanced performance in the lesion-group in terms of shorter session times and PRPs. During the sessions we found that the lesion-group spent less time with non-instrumental behavior (i.e., grooming, sniffing, and rearing) after prolonged instrumental training. Also, such rats showed moderate evidence for an extinction impairment under devalued food reward conditions and significant deficits in a response-outcome (R-O)-discrimination task in comparison to a control-group. These findings suggest that facilitatory effects on instrumental performance after dorsal hippocampal lesions may be primarily a result of complex behavioral changes, i.e., reductions of behavioral flexibility and/or alterations in motivation, which then result in enhanced instrumental learning.
机译：本研究是一系列实验的一部分，我们在其中分析了大鼠背侧海马（dHC）的破坏原因以及如何增强其在顺序反应时间任务（SRTT）中的表现。在此任务中，以固定的比例13计划奖励不同视觉刺激呈现的序列。我们先前的研究（Busse和Schwarting，）表明，患有dHC损伤的大鼠的会话时间和强化后停顿（PRP）均比对照组短，这使得在每天训练保持恒定的情况下可以进行更多的练习。由于顺序行为是基于工具性能的，因此顺序好处可能是次要的。为了在本研究中检验这一假设，我们进行了两个实验，其中在具有兴奋性毒性背海马损伤的大鼠中使用伪随机而非顺序刺激。再次，我们发现，在更短的会话时间和PRP方面，病变组的性能得到了提高。在会议期间，我们发现病变组在长时间的器械训练后花在非器械行为（即梳理，嗅探和抚养）上的时间更少。此外，与对照组相比，这类大鼠在适度的食物奖励条件下显示出灭绝障碍，并且在响应结果（R-O）歧视任务中存在明显缺陷。这些发现表明，对背侧海马损伤后的仪器性能的促进作用可能主要是复杂的行为变化的结果，即行为灵活性的降低和/或动机的改变，然后导致仪器学习的增强。

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