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Anti-diabetic effects of mulberry (Morus alba L.) branches and oxyresveratrol in streptozotocin-induced diabetic mice

机译:桑树分支和氧白藜芦醇对链脲佐菌素诱导的糖尿病小鼠的抗糖尿病作用

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摘要

Despite with accumulating evidences on the anti-diabetic effects of mulberry branch (MB), the major active component for the activity has not been known. Oral administration of MB ethanol (EtOH) extracts [0.5 or 1 g/kg body weight (BW)] once a day for 22 days to streptozotocin-induced diabetic ICR mouse significantly reduced fasting blood and plasma glucose level in a dose dependent manner compared to those of the diabetic control. Administration of oxyresveratrol [ORT, 0.6 g/kg BW], a major compound of MB EtOH extracts, to diabetic ICR mouse also significantly reduced fasting plasma glucose level. Further, ORT increased hepatic glucose transporter 2 transcription and glycogen content. Plasma insulin concentration and intestinal disaccharidase activity were not different between diabetic control and ORT groups. This suggests that ORT reduced plasma glucose by stimulating hepatic glucose uptake and glycogen storage. MB EtOH extracts and ORT could be potential adjunct therapies for diabetes management.
机译:尽管有关于桑树分支(MB)的抗糖尿病作用的证据,但尚不清楚该活性的主要活性成分。与链脲佐菌素诱导的糖尿病ICR小鼠相比,每天口服MB乙醇(EtOH)提取物[0.5或1 g / kg体重(BW)]连续22天,与剂量相比,其剂量依赖性显着降低了空腹血液和血浆葡萄糖水平那些由糖尿病控制的。给糖尿病ICR小鼠服用氧白藜芦醇[ORT,0.6 g / kg BW],MB EtOH提取物的主要化合物,也显着降低了空腹血糖水平。此外,ORT增加了肝葡萄糖转运蛋白2转录和糖原含量。糖尿病对照组和ORT组之间的血浆胰岛素浓度和肠二糖酶活性没有差异。这表明ORT通过刺激肝葡萄糖摄取和糖原贮积来降低血浆葡萄糖。 MB EtOH提取物和ORT可能是糖尿病管理的潜在辅助疗法。

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