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The song of the old mother: Reproductive senescence in female drosophila

机译:老母亲的歌:果蝇雌性的生殖衰老

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摘要

Among animals with multiple reproductive episodes, changes in adult condition over time can have profound effects on lifetime reproductive fitness and offspring performance. The changes in condition associated with senescence can be particularly acute for females who support reproductive processes from oogenesis through fertilization. The pomace fly Drosophila melanogaster is a well-established model system for exploring the physiology of reproduction and senescence. In this review, we describe how increasing maternal age in Drosophila affects reproductive fitness and offspring performance as well as the genetic foundation of these effects. Describing the processes underlying female reproductive senescence helps us understand diverse phenomena including population demographics, condition-dependent selection, sexual conflict, and transgenerational effects of maternal condition on offspring fitness. Understanding the genetic basis of reproductive senescence clarifies the nature of life-history trade-offs as well as potential ways to augment and/or limit female fertility in a variety of organisms.
机译:在具有多个生殖事件的动物中,成年状况随时间的变化可能会对终生生殖健康和后代表现产生深远影响。与衰老相关的状况变化对于支持从卵子发育到受精的生殖过程的女性而言尤其严重。果蝇果蝇果蝇是一种成熟的模型系统,用于探索生殖和衰老的生理学。在这篇综述中,我们描述了果蝇中产妇年龄的增加如何影响生殖健康和后代表现以及这些影响的遗传基础。描述女性生殖衰老的过程有助于我们理解各种现象,包括人口统计学,条件依赖的选择,性冲突以及母体条件对后代适应性的跨代影响。了解生殖衰老的遗传基础可以阐明生命史权衡的性质,以及在各种生物体中增加和/或限制女性生育力的潜在途径。

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