• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Experimental Biology and Medicine >Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma
【2h】

Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma

机译：简讯：专题文章：组蛋白H2A单泛素化和细胞转化与N-亚硝基二乙胺诱导的肝细胞癌呈负相关

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aberrant changes in histone post-translational modifications are encountered frequently in diseases like cancer. Although histone H3 post-translational modifications have been extensively studied in context of diseases, the functionally important histone H2A PTM H2A119ub (H2Aub) has not gained much attention. In this study, we report that H2Aub markedly decreases in hepatocellular carcinoma. Usp21, a H2A deubiquitinase, is probably responsible for decrease in H2Aub. In addition, the H2Aub levels showed an inverse correlation with H3S10 phosphorylation (H3S10p) and the proliferative state of the cells. Downregulation of H2Aub is also associated with increased expression of growth factor gene lipocalin 2. Interestingly, we show that treatment of cells with histone deacetylase inhibitor trichostatin A results in increase of H2Aub and decrease in H3S10p. Our work for the first time suggests the in vivo association of H3S10p, H4ac, and H2A119ub with cellular transformation.
机译：在诸如癌症的疾病中经常遇到组蛋白翻译后修饰的异常变化。尽管已经在疾病方面对组蛋白H3的翻译后修饰进行了广泛研究，但是功能上重要的组蛋白H2A PTM H2A119ub（H2Aub）并未引起太多关注。在这项研究中，我们报告H2Aub在肝细胞癌中显着降低。 Usp21是一种H2A去泛素酶，可能是H2Aub减少的原因。另外，H2Aub水平与H3S10磷酸化（H3S10p）和细胞的增殖状态呈负相关。 H2Aub的下调也与生长因子基因lipocalin 2的表达增加有关。有趣的是，我们显示，用组蛋白脱乙酰基酶抑制剂曲古抑菌素A处理细胞会导致H2Aub升高而H3S10p降低。我们的工作首次提出了H3S10p，H4ac和H2A119ub与细胞转化的体内关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号