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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Functions of Danggui Buxue Tang a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent
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Functions of Danggui Buxue Tang a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent

机译：当归补血汤是黄芪和当归的中药汤在子宫和肝脏中的功能均与雌激素受体有关与雌激素受体无关

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Danggui Buxue Tang (DBT), a herbal decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), has been used in treating menopausal irregularity in women for more than 800 years in China. Pharmacological results showed that DBT exhibited significant estrogenic properties in vitro, which therefore suggested that DBT could activate the nuclear estrogen receptors. Here, we assessed the estrogenic properties of DBT in an ovariectomized in vivo rat model: DBT was applied to the ovariectomized rats for 3 days. The application of DBT did not alter the weight of uterus and liver, as well as the transcript expression of the proliferation markers including the estrogen receptors α and β. However, DBT stimulated the transcript expression of the estrogen responsive genes. In addition, the inductive role of DBT on the expression of members of the aryl hydrocarbon receptor family in uterus and liver of ovariectomized rats was confirmed. These responses of DBT however were clearly distinct from the response pattern detectable here for 17β-estradiol. Therefore, DBT exhibited weak, but significant, estrogenic properties in vivo; however, some of its activities were independent of the estrogen receptor. Thus, DBT could be an exciting Chinese herbal decoction for an alternative treatment of hormone replacement therapy for women in menopause without subsequent estrogenic side effects.
机译：当归补血汤（DBT）是一种含有黄芪（Angelicae Radix，AR）和当归（Angelicae Sinensis Radix，ASR）的草药汤，在中国已用于治疗女性更年期不规则症已有800多年的历史。药理结果表明，DBT在体外显示出明显的雌激素特性，因此表明DBT可以激活核雌激素受体。在这里，我们评估了在切除卵巢的体内大鼠模型中DBT的雌激素特性：将DBT应用于切除卵巢的大鼠3天。 DBT的应用不会改变子宫和肝脏的重量，也不会改变包括雌激素受体α和β在内的增殖标志物的转录表达。但是，DBT刺激雌激素反应基因的转录表达。另外，证实了DBT对去卵巢大鼠子宫和肝脏中芳烃受体家族成员表达的诱导作用。然而，DBT的这些反应明显不同于此处可检测到的17β-雌二醇的反应模式。因此，DBT在体内显示出弱但重要的雌激素特性。但是，其某些活性独立于雌激素受体。因此，DBT可能是一种令人振奋的中药汤剂，可​​用于更年期妇女的激素替代疗法的替代疗法，而没有随后的雌激素副作用。

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