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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major
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In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major

机译：黄连木对热带利什曼原虫和大利什曼原虫的体外和体内抗利什曼作用

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The present study aims to evaluate the in vitro and in vivo antileishmanial activities of Pistacia khinjuk Stocks (Anacardiaceae) alcoholic extract and to compare its efficacy with a reference drug, meglumine antimoniate (MA, Glucantime), against Leishmania tropica and Leishmania major. This extract (0–100 µg/mL) was evaluated in vitro against promastigote and intracellular amastigote forms of L. tropica (MRHO/IR/75/ER) and then tested on cutaneous leishmaniasis (CL) in male BALB/c mice with L. major to reproduce the antileishmanial activity topically. In vitro, P. khinjuk extract significantly (P < 0.05) inhibited the growth rate of promastigote (IC50 58.6 ± 3.2 µg/mL) and intramacrophage amastigotes (37.3 ± 2.5 µg/mL) of L. tropica as a dose-dependent response. In the in vivo assay, after 30 days of treatment, 75% recovery was observed in the infected mice treated with 30% extract. After treatment of the subgroups with the concentration of 20 and 30% of P. khinjuk extract, mean diameter of lesions was significantly (P < 0.05) reduced. To conclude, the present investigation demonstrated that P. vera extract had in vitro and in vivo effectiveness against L. major. Obtained findings also provide the scientific evidences that natural plants could be used in the traditional medicine for the prevention and treatment of CL.
机译：本研究旨在评估黄连木茎（Anacardiaceae）酒精提取物的体外和体内抗菊苣活性，并将其与参比药物葡甲胺锑酸盐（MA，Glucantime）对热带利什曼原虫和主要利什曼原虫的功效进行比较。对该提取物（0–100μg / mL）进行了体外抗热带疟原虫前鞭毛体和胞内鞭毛体形式（MRHO / IR / 75 / ER）的评估，然后在雄性BALB / c小鼠中检测了皮肤利什曼病（CL）专业重现局部的反讽活动。在体外，P。khinjuk提取物显着（P <0.05）抑制热带疟原虫的前鞭毛体（IC50 58.6±3.2μg/ mL）和巨噬细胞内变形虫（37.3±2.5μg/ mL）的生长，呈剂量依赖性。在体内试验中，治疗30天后，在用30％提取物治疗的受感染小鼠中观察到75％的恢复。用浓度分别为20％和30％的 P. khinjuk 提取物治疗亚组后，平均皮损直径显着降低（ P <0.05）。总而言之，本研究表明，真假单胞菌提取物具有抗 L。major 的体外和体内功效。 >。获得的发现还提供了科学证据，证明天然植物可用于预防和治疗CL的传统药物中。

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