• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis
【2h】

Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis

机译：表现为血瘀型脑梗死患者临床血浆的代谢组学分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Blood stasis (BS) is characterized as a disorder of blood circulation. In traditional Korean medicine (TKM), it is viewed as a cause factor of diseases such as multiple sclerosis and stroke. This study investigated differences in the plasma metabolites profiles of subjects displaying BS or non-BS patterns. Thirty-one patients with cerebral infarction diagnosed with BS and an equal number of sex- and age-matched non-BS patients were enrolled. Metabolic profiling was performed using UPLC-MS. The ratio of subjects with a rough pulse and purple coloration of the tongue was higher in patients presenting with BS pattern. Through metabolomics analysis, 82 metabolites that differed significantly between the BS and non-BS pattern were identified, and the two groups were significantly separated using an orthogonal partial least square-discriminant analysis model (P < 0.001). Of these 82 metabolites, acetyl carnitine, leucine, kynurenine, phosphocholine, hexanoyl carnitine, and decanoyl carnitine were present in significantly higher levels in patients with a BS pattern than those with a non-BS pattern. Our results also demonstrated that seven plasma metabolites, including acyl-carnitines and kynurenine, were associated with a BS pattern, suggesting that variant plasma metabolic profiles may serve as a biomarker for diagnosis of BS in patients with cerebral infarction.
机译：血瘀（BS）的特征是血液循环障碍。在传统的韩国医学（TKM）中，它被视为导致多发性硬化和中风等疾病的原因。这项研究调查了显示BS或非BS模式的受试者血浆代谢产物谱的差异。研究入组了31例诊断为BS的脑梗死患者，以及同等数量的性别和年龄匹配的非BS患者。使用UPLC-MS进行代谢谱分析。出现BS模式的患者中，脉搏粗糙和舌紫色的受试者比例更高。通过代谢组学分析，鉴定出BS模式和非BS模式之间有显着差异的82种代谢物，并且使用正交偏最小二乘判别分析模型将两组显着分离（P <0.001）。在这82种代谢产物中，具有BS模式的患者中的乙酰肉碱，亮氨酸，犬尿氨酸，磷酸胆碱，己酰基肉碱和癸酰基肉碱的含量明显高于非BS模式的患者。我们的研究结果还表明，七种血浆代谢物（包括酰基肉碱和犬尿氨酸）与BS模式有关，这表明血浆血浆代谢谱变异可能是诊断脑梗死患者BS的生物标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号