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Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation

机译：常见的MLL / COMPASS亚基和19S蛋白酶体在调节CIITA pIV和MHC II类基因表达以及启动子甲基化中的作用

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BackgroundStudies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S proteasome are crucial for regulating inducible histone activation events in mammalian cells. The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC)-II and class II transactivator (CIITA) promoters, implicating Sug1 in events required to initiate mammalian transcription.

机译：背景研究表明19S蛋白酶体有助于染色质重组，而与蛋白酶体在蛋白质降解中的作用无关。先前我们已经表明19S蛋白酶体的成分对于调节哺乳动物细胞中可诱导的组蛋白活化事件至关重要。 19S ATPase Sug1与组蛋白重塑酶结合，在不存在Sug1的情况下，在细胞因子诱导的主要组织相容性复合物（MHC）上抑制了激活的表观遗传修饰的子集，包括组蛋白H3乙酰化，H3赖氨酸4三甲基化和H3精氨酸17甲基化。 -II和II类反式激活子（CIITA）启动子，在启动哺乳动物转录所需的事件中涉及Sug1。

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期刊名称 Epigenetics Chromatin
作者
Olivia I Koues; Ninad T Mehta; Agnieszka D Truax; R Kyle Dudley; Jeanne K Brooks; Susanna F Greer;
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年(卷),期 2010(3),-1
年度 2010
页码 5
总页数 11
原文格式 PDF
正文语种
中图分类遗传学;
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专利

1. Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation [J] . Olivia I Koues, Ninad T Mehta, Agnieszka D Truax, Epigenetics & Chromatin . 2010,第1期

机译：常见的MLL / COMPASS亚基和19S蛋白酶体在调节CIITA pIV和MHC II类基因表达以及启动子甲基化中的作用
2. Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5′-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes [J] . Nienke van der Stoep, Edwin Quinten, Peter J. van den Elsen The journal of immunology . 2002,第9期

机译：MHC II类反式激活子（CIITA）启动子III的转录调控：5'-非翻译区的新型调控区的鉴定以及cAMP-响应元件结合蛋白1和激活转录因子1在CIITA-中的重要作用B淋巴细胞中的启动子III转录激活
3. Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5′-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes [J] . Nienke van der Stoep, Edwin Quinten, Peter J. van den Elsen The journal of immunology . 2002,第9期

机译：MHC II类反式激活子（CIITA）启动子III的转录调控：5'-非翻译区的新型调控区的鉴定以及cAMP-响应元件结合蛋白1和激活转录因子1在CIITA-中的重要作用B淋巴细胞中的启动子III转录激活
4. OVEREXPRESSION OF ELFN2 IN GLIOMA REGULATED BY GENE PROMOTER HYPOMETHYLATION [C] . Liu Xiaoping, Yu Zhibin, Wang Zeyou, Progress on post-genome technologies and modern natural products . 2011

机译：基因启动子过甲基化调节胶质瘤中ELFN2的过表达
5. The 26s proteasome and histone modifying enzymes regulate transcription of the class II transactivator, CIITA. [D] . Truax, Agnieszka D. 2011

机译：26年代的蛋白酶体和组蛋白修饰酶调节II类反式激活子CIITA的转录。
6. Decreased MHC class II expression in diffuse large B-cell lymphoma does not correlate with CpG methylation of CIITA promoters III and IV [O] . SARAH T. WILKINSON, DIANE R. FERNANDEZ, SHAWN P. MURPHY, -1

机译：降低mHC类在弥漫性大B细胞淋巴瘤II表达不相关与CIITa启动子Ⅲ和Ⅳ的CpG甲基化
7. Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation [O] . Koues Olivia I, Mehta Ninad T, Truax Agnieszka D, 2010

机译：常见的MLL / COMPASS亚基和19S蛋白酶体在调节CIITA pIV和MHC II类基因表达以及启动子甲基化中的作用

Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation

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