Homeland security in the C. elegans germ line

机译：秀丽隐杆线虫种系的国土安全

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While most eukaryotic genomes contain transposable elements that can provide select evolutionary advantages to a given organism, failure to tightly control the mobility of such transposable elements can result in compromised genomic integrity of both parental and subsequent generations. Together with the Piwi subfamily of Argonaute proteins, small, non-coding Piwi-interacting RNAs (piRNAs) primarily function in the germ line to defend the genome against the potentially deleterious effects that can be caused by transposition. Here, we describe recent discoveries concerning the biogenesis and function of piRNAs in the nematode Caenorhabditis elegans, illuminating how the faithful production of these mature species can impart a robust defense mechanism for the germ line to counteract problems caused by foreign genetic elements across successive generations by contributing to the epigenetic memory of non-self vs. self.

机译：尽管大多数真核生物基因组都包含可为给定生物提供选择进化优势的转座因子，但不能严格控制此类转座因子的迁移性会导致亲代和后代的基因组完整性受损。小型的非编码Piwi相互作用RNA（piRNA）与Argonaute蛋白的Piwi子家族一起主要在种系中发挥功能，以保护基因组免受可能因转座引起的潜在有害作用。在这里，我们描述了有关线虫秀丽隐杆线虫中piRNA的生物发生和功能的最新发现，阐明了这些成熟物种的忠实生产如何能够为种系赋予强大的防御机制，以抵消由连续几代人的外来遗传因素引起的问题。有助于非自我与自我的表观遗传记忆。

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期刊名称 Epigenetics
作者
Dionna M Kasper; Kathryn E Gardner; Valerie Reinke;
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年(卷),期 2014(9),1
年度 2014
页码 62–74
总页数 13
原文格式 PDF
正文语种
中图分类分子生物学;
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专利

1. Homeland security in the C. elegans germ line: Insights into the biogenesis and function of pirnas [J] . KasperD.M., GardnerK.E., ReinkeV. Epigenetics: official journal of the DNA Methylation Society . 2014,第1期

机译：秀丽隐杆线虫种系中的国土安全：对皮尔纳斯生物发生和功能的认识
2. GLD-4-Mediated Translational Activation Regulates the Size of the Proliferative Germ Cell Pool in the Adult C. elegans Germ Line [J] . Sophia Millonigg, Ryuji Minasaki, Marco Nousch, PLoS Genetics . 2014,第9期

机译：GLD-4介导的翻译激活调节成人 C中增殖性生殖细胞池的大小。线虫胚芽系
3. Germ cell survival in C. elegans and C. remanei is affected when the dead box RNA helicases VBH-1 or Cre-VBH-1 are silenced. [J] . Salinas L. S., Franco-Cea A., Lascarez-Lagunas L. I., Genesis: the journal of genetics and development . 2012,第11期

机译：当死框RNA解旋酶VBH-1或Cre-VBH-1沉默时，会影响线虫和remanei的生殖细胞存活。
4. Si elegans: Evaluation of an innovative optical synaptic connectivity method for C. elegans Phototaxis using FPGAs [C] . Pedro Machado, Alicia Costalago Meruelo, Nikesh Lama, International Joint Conference on Neural Networks . 2016

机译：秀丽线虫：使用FPGA的秀丽线虫趋光性的创新光学突触连接方法的评估
5. Assessing the Role of Germ Granules in Germline Development and Organismal Aging in C. elegans. [D] . Knutson, Andrew Kekupa'a. 2016

机译：评估胚芽颗粒在秀丽隐杆线虫生殖发育和生物衰老中的作用。
6. Review of Bioterrorism: Mathematical modeling applications in homeland security by H. T. Banks and C. Castillo-Chavez [O] . Ming Jiang 2005

机译：H. T. Banks和C. Castillo-Chavez撰写的生物恐怖主义：数学建模在国土安全中的应用评论
7. Existence of four acetylcholinesterase genes in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae1Accession numbers: ace-1: X75331 (C. elegans), U41846 (C. briggsae); ace-2: AF025378 (C. elegans), AF030037 (C. briggsae); ace-x: AF025379 (C. elegans); ace-y: AF039650 (C. elegans). Sequences of ace-x and ace-y in C. briggsae were released by the GSC (St. Louis, MO, USA) from phosmid G18H21.1 [O] . Grauso Marta, Culetto Emmanuel, Combes Didier, 1998

机译：线虫Caenorhabditis elegans和Caenorhabditis briggsae1中存在四个乙酰胆碱酯酶基因。登录号：ace-1：X75331（C。elegans），U41846（C。briggsae）； ace-2：AF025378（秀丽隐杆线虫），AF030037（秀丽隐杆线虫）； ace-x：AF025379（秀丽线虫）; ace-y：AF039650（秀丽隐杆线虫）。 GSC（美国密苏里州圣路易斯）从磷酰胺G18H21.1中释放了桥生梭菌中ace-x和ace-y的序列

Homeland security in the C. elegans germ line

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