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首页> 美国卫生研究院文献>Environmental Health Perspectives >Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.
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Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.

机译：饮食接触叙利亚金仓鼠中的铁石棉和温石棉的慢性影响。

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摘要

Bioassays of amosite, short-range (SR), intermediate-range (IR) or intermediate-range chrysotile asbestos in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) were conducted with male and female Syrian golden hamsters. Amosite and both forms of chrysotile asbestos were administered at a concentration of 1% in pelleted diet for the entire lifetime of the hamsters starting with mothers of the test animals. Group sizes varied from 125-254. There was no adverse effect on body weight gain or survival by either type of asbestos or by IR chrysotile asbestos in combination with DMH. A significant increase (p less than 0.05) in adrenal cortical tumors was observed in male hamsters exposed to SR and IR chrysotile asbestos and in females treated with IR chrysotile asbestos when compared to the pooled control groups. However, statistical significance (p less than 0.05) was lost when these dosed groups were compared with temporal control groups. Neither of the male or female amosite asbestos groups showed increased neoplasia in any tissue or organ compared to the control groups. The cocarcinogen studies using IR chrysotile asbestos and 1,2-dimethylhydrazine dihydrochloride were considered inadequate because there was no increase in intestinal neoplasia in the DMH group.
机译：对雄性和雌性叙利亚金仓鼠进行了肠，短程（SR），中程（IR）或中程温石棉石棉与肠道致癌物1,2-二甲基肼二盐酸盐（DMH）结合的生物测定。从仓鼠的整个生命中开始，从试验动物的母亲开始，以粒状饮食中的铁石棉和两种形式的温石棉石棉的浓度为1％。小组人数从125-254不等。石棉类型或IR温石棉石棉与DMH结合使用不会对体重增加或存活产生不利影响。与混合对照组相比，在暴露于SR和IR温石棉石棉的雄性仓鼠和接受IR温石棉石棉治疗的雌性中，观察到肾上腺皮质肿瘤显着增加（p小于0.05）。但是，将这些剂量组与时间对照组进行比较时，统计学意义（p小于0.05）丧失了。与对照组相比，男性和女性无烟石棉组均未在任何组织或器官中显示出增生。认为使用IR温石棉和1,2-二甲基肼二盐酸盐进行的致癌研究不充分，因为DMH组的肠肿瘤没有增加。

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