Evaluation of the exposure, dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, crocidolite or amosite asbestos in a 90-day quantitative inhalation toxicology study - Interim results Part 1: Experimental design, aerosol exposure, lung burdens and BAL

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Evaluation of the exposure, dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, crocidolite or amosite asbestos in a 90-day quantitative inhalation toxicology study - Interim results Part 1: Experimental design, aerosol exposure, lung burdens and BAL

机译：与TiO2，Chrysotile，Crocidoolite的肺部肺部和胸膜肺炎中的肺和胸膜肺炎中的暴露，剂量 - 反应和命运评价为90天定量吸入毒理学研究 - 中期结果第1部分：试验设计，气溶胶曝光，肺负担和bal

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This 90-day repeated -dose inhalation toxicology study of brake-dust (BD) (brakes manufactured with chrysotile) in rats provides a comprehensive understanding of the biokinetics and potential toxicology in the lung and pleura. Exposure was 6 h/d, 5d/wk., 13wks followed by lifetime observation (similar to 20 % survival). Control groups included a particle control (TiO2), chrysotile, commercial crocidolite and amosite asbestos.

机译：大鼠制动除尘（BD）（用菊花制造的制动器制造的制动器）的90天重复糖吸入毒理学研究提供了对肺和胸膜的生物机和潜在毒理学的全面了解。暴露是6h / d，5d / wp。，13wk，后跟寿命观察（类似于20％存活）。对照组包括颗粒对照（TiO 2），Chrysotile，商业番茄和余产石棉。

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《Toxicology and Applied Pharmacology》 |2020年第2020期|共17页
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正文语种 eng
中图分类毒物学（毒理学）;
关键词
Inhalation; Toxicology; Brake dust; Chrysotile; Crocidolite; Amosite;

机译：吸入;毒理学;制动粉尘;Chrysotile;Crocidolite;适用;

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1. Evaluation of the exposure, dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, crocidolite or amosite asbestos in a 90-day quantitative inhalation toxicology study - Interim results Part 1: Experimental design, aerosol exposure, lung burdens and BAL [J] . Toxicology and Applied Pharmacology . 2020,第期

机译：与TiO2，Chrysotile，Crocidoolite的肺部肺部和胸膜肺炎中的肺和胸膜肺炎中的暴露，剂量 - 反应和命运评价为90天定量吸入毒理学研究 - 中期结果第1部分：试验设计，气溶胶曝光，肺负担和bal
2. Evaluation of the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to chrysotile or crocidolite asbestos in a 28-day quantitative inhalation toxicology study [J] . Bernstein D. M., Toth B., Rogers R. A., Toxicology and Applied Pharmacology . 2018,第期

机译：在28天定量吸入毒理学研究中，评估含甜硅酸盐制动粉尘的肺部和胸腔的肺部和胸膜的命运和命运
3. Evaluation of the dose-response and fate in the lung and pleura of chrysotile containing brake dust compared to chrysotile or crocidolite asbestos in a 28 day inhalation toxicology study [J] . Toth B., Bernstein D. M., Rogers R. A., Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2018,第期

机译：在28天吸入毒理学研究中，评估含甜于甲基含油粉的瘤瘤和克瑞氏菌的肺炎和葡萄牙肺炎的剂量 - 反应和命运
4. Quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite-asbestos following short-term inhalation exposure [O] . DM Bernstein, RA Rogers, R Sepulveda, -1

机译：短期吸入后与温石棉和石棉相结合的定量的温石棉肺和胸膜的病理反应和命运的定量
5. Evaluation of the fate and pathological response in the lung and pleura of brake dust alone and in combination with added chrysotile compared to crocidolite asbestos following short-term inhalation exposure [O] . Bernstein D.M., Rogers R.A., Sepulveda R., 2015

机译：评估短期吸入后与青石棉石棉相比，单独和与添加的温石棉相结合的刹车粉对肺和胸膜的命运和病理反应

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