• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Environmental Health Perspectives >Toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies.
【2h】

Toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies.

机译：吸入异氰酸甲酯对F344 / N大鼠和B6C3F1小鼠的毒性。 I.急性接触和恢复研究。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Male and female F344/N rats and B6C3F1 mice were exposed to lethal and sublethal concentrations of methyl isocyanate by inhalation. Mortality, clinical signs, body and organ weights, and changes in clinical pathology and hematology were monitored immediately after 2-hr exposures and during the ensuing 3 months. Additional studies investigated the possible involvement of cyanide in the toxicity of methyl isocyanate. During exposures, signs of restlessness, lacrimation, and a reddish discharge from the nose and mouth were evident in rats and mice. Following exposures, rats and mice were dyspneic and weak. Deaths of rats and mice exposed to lethal concentrations (20 to 30 ppm) began within 15-18 hr, with males more prone to early death than females. A second wave of deaths occurred after 8 to 10 days, affecting primarily female rats and mice exposed to 20 to 30 ppm of methyl isocyanate, and male and female rats exposed to 10 ppm. Most deaths occurred during the first month following the exposures and were preceded by periods of severe respiratory distress. Body weights decreased in proportion to dose early, but then weight gain resumed in survivors at control rates. The only organ with a consistent, dose-related weight change was the lung, which was heavier throughout the studies in animals exposed to high concentrations of methyl isocyanate. No significant clinical pathology, or hematologic changes were observed in exposed rats. Blood and brain cholinesterase were not inhibited. Studies attempting to measure cyanide in the blood of methyl isocyanate-exposed rats, and attempting to affect lethality with a cyanide antidote (sodium nitrite and sodium thiosulfate) gave negative results.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：雄性和雌性F344 / N大鼠和B6C3F1小鼠通过吸入暴露于致死和致死浓度的异氰酸甲酯。在暴露2小时后以及随后的3个月内立即监测死亡率，临床体征，体重和器官重量以及临床病理学和血液学变化。其他研究调查了氰化物可能参与异氰酸甲酯的毒性。在暴露期间，在大鼠和小鼠中明显出现躁动，流泪和鼻子和嘴巴发红的迹象。暴露后，大鼠和小鼠呼吸困难且虚弱。暴露于致死浓度（20至30 ppm）的大鼠和小鼠的死亡在15-18小时内开始，雄性比雌性更容易发生早期死亡。 8至10天后发生第二次死亡，主要影响雌性大鼠和暴露于20至30 ppm异氰酸甲酯的小鼠，雄性和雌性大鼠暴露于10 ppm。大多数死亡发生在接触后的第一个月，然后是严重的呼吸窘迫期。体重与剂量的早期成比例地降低，但是幸存者以控制率恢复了体重增加。唯一与剂量相关的体重变化一致的器官是肺，在整个研究中，暴露于高浓度异氰酸甲酯的动物中肺较重。在裸露的大鼠中未观察到明显的临床病理或血液学变化。血液和脑胆碱酯酶没有被抑制。尝试测量暴露于异氰酸甲酯的大鼠血液中氰化物并尝试使用氰化物解毒剂（亚硝酸钠和硫代硫酸钠）影响致死性的研究得出了负面结果。（摘要截断为250字）

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号