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首页> 美国卫生研究院文献>The Malaysian Journal of Medical Sciences : MJMS >Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells’ Extracellular Vesicles
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Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells’ Extracellular Vesicles

机译：推进有效的胶质瘤治疗：脐带间充质干细胞的细胞外囊泡衍生的MicroRNA

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摘要

A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas’ ability to develop resistance to chemotherapies. Moreover, glioma stem cells (GSC) contribute to maintaining the glioma population, which benefits from its ability to self-renew and differentiate. Recent research has reported that through the introduction of umbilical cord mesenchymal stem cells (UCMSC) into glioma cells, the growth and development of the glioma cells can be downregulated. It has more currently been found out that UCMSC release extracellular vesicles (EVs) containing miRNA that are responsible for this phenomenon. Therefore, this review analyses literature to discuss all possible miRNAs contained within the UCMSC’s EVs and to elaborate on their molecular mechanisms in halting gliomas and GSC growth. This review will also include the challenges and limitations, to account for which more in vivo research is suggested. In conclusion, this review highlights how miRNAs contained within UCMSC’s EVs are able to downregulate multiple prominent pathways in the survival of gliomas.
机译：胶质瘤，特别是IV级胶质母细胞瘤，是一种恶性肿瘤，尽管医学进步不断，但预后较差。由于胶质母细胞瘤对化学疗法产生耐药性，研究人员一直在寻找针对神经胶质瘤分子途径的更好，更有效的治疗方法。此外，神经胶质瘤干细胞（GSC）有助于维持神经胶质瘤的数量，这得益于其自我更新和分化的能力。最近的研究报道，通过将脐带间充质干细胞（UCMSC）引入神经胶质瘤细胞中，可以下调神经胶质瘤细胞的生长和发育。目前已经发现，UCMSC释放出引起这种现象的含有miRNA的细胞外囊泡（EV）。因此，这篇综述分析了文献，以讨论UCMSC电动汽车中包含的所有可能的miRNA，并详细阐述了它们在阻止神经胶质瘤和GSC生长中的分子机制。这篇综述还将包括挑战和局限性，以说明建议进行更多体内研究的原因。总之，这篇综述着重介绍了UCMSC EV中包含的miRNA如何能够下调神经胶质瘤生存中的多个重要途径。

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