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Overexpression of both platelet-derived growth factor-BB and vascular endothelial growth factor-C and its association with lymphangiogenesis in primary human non-small cell lung cancer

机译:血小板衍生生长因子-BB和血管内皮生长因子-C的过表达及其与原发性人类非小细胞肺癌的淋巴管生成的关系

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摘要

AbstractBackgroundMetastatic spread of tumor through lymphatic vasculature is an important adverse prognostic factor in a variety of human cancer and tumor lymphangiogenesis requires the interplay of several growth factors. Platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C are two important molecules involving in tumor metastasis and lymphangiogenesis. Therefore, the aim of this study was to investigate the coexpression of PDGF-BB and VEGF-C in primary human non-small cell lung cancer (NSCLC) and its association with lymphangiogenesis.
机译:摘要背景肿瘤通过淋巴管的转移是许多人类癌症的重要不良预后因素,而肿瘤淋巴管生成需要多种生长因子的相互作用。血小板衍生生长因子(PDGF)-BB和血管内皮生长因子(VEGF)-C是涉及肿瘤转移和淋巴管生成的两个重要分子。因此,本研究的目的是研究PDGF-BB和VEGF-C在原发性人类非小细胞肺癌(NSCLC)中的共表达及其与淋巴管生成的关系。

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