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Potential of Bone Marrow Stromal Cells in Applications for Neuro-Degenerative Neuro-Traumatic and Muscle Degenerative Diseases

机译:骨髓基质细胞在神经退行性神经外伤性和肌肉退行性疾病中的应用潜力

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摘要

Cell transplantation is a promising strategy for the treatment of neurodegenerative and muscle degenerative diseases. Many kinds of cells, including embryonic stem cells and tissue stem cells, have been considered as candidates for transplantation therapy. Bone marrow stromal cells >(MSCs) have great potential as therapeutic agents since they are easy to isolate and can be expanded from patients without serious ethical or technical problems. We discovered a new method for the highly efficient and specific induction of functional Schwann cells, neurons and skeletal muscle lineage cells from both rat and human >MSCs. These induced cells were transplanted into animal models of neurotraumatic injuries, Parkinson’s disease, stroke and muscle dystrophies, resulting in the successful integration of transplanted cells and an improvement in behavior of the transplanted animals. Here we focus on the respective potentials of >MSC-derived cells and discuss the possibility of clinical application in degenerative diseases.
机译:细胞移植是治疗神经退行性疾病和肌肉退行性疾病的一种有前途的策略。包括胚胎干细胞和组织干细胞在内的多种细胞已被认为是移植治疗的候选者。骨髓基质细胞>(MSCs)具有巨大的治疗潜力,因为它们易于分离并且可以从患者身上扩增而不会出现严重的伦理或技术问题。我们发现了一种新的方法,可以从大鼠和人> MSC 中高效,特异地诱导功能性雪旺细胞,神经元和骨骼肌谱系细胞。这些诱导的细胞被移植到神经外伤,帕金森氏病,中风和肌肉营养不良的动物模型中,从而成功地整合了移植细胞并改善了移植动物的行为。在这里,我们集中于> MSC 来源的细胞的各自潜力,并讨论在退行性疾病中临床应用的可能性。

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