• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Veterinary Research Forum >Interrelationship of βeta-2 microglobulin blood urea nitrogen and creatinine in streptozotocin-induced diabetes mellitus in rabbits
【2h】

Interrelationship of βeta-2 microglobulin blood urea nitrogen and creatinine in streptozotocin-induced diabetes mellitus in rabbits

机译：βeta-2微球蛋白血尿素氮和肌酐在链脲佐菌素诱发的糖尿病兔中的相互关系

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Measurement of serum creatinine (Cr) and blood urea nitrogen (BUN) are used as indicators of glomerular filtration rate. The increased levels of these biomarkers are usually detectable at advanced stages of kidney complications. The aim of this study was to find the interrelationship of beta-2 microglobulin (β2M), BUN and Cr in streptozotocin (STZ)-induced diabetes mellitus in rabbits. Diabetes was induced by a single intraperitoneal (IP) injection of 65 mg kg-1 of STZ in rabbits. The levels of serum insulin, glucose and three above mentioned biomarkers were measured one day before (day -1) and on days 1-3 after injection of STZ and continued weekly to the end of the experiment (12 weeks). A statistically significant increase of serum β2M, BUN, Cr and glucose levels, and a significant decrease of insulin levels were observed in diabetic animals. However, β2M levels increased as early as one day after STZ injection compared to Cr and BUN that elevated at day two, suggesting a probable diagnostic advantage of β2M over currently used biomarkers in diabetic related kidney complications.
机译：血清肌酐（Cr）和血尿素氮（BUN）的测量用作肾小球滤过率的指标。这些生物标志物水平的升高通常在肾脏并发症的晚期可以检测到。这项研究的目的是发现链脲佐菌素（STZ）诱导的兔糖尿病中β-2微球蛋白（β2M），BUN和Cr之间的相互关系。腹膜内（IP）单次注射兔体内65 mg kg -1 的STZ可诱发糖尿病。在注射STZ的前一天（第-1天）和第1-3天测量血清胰岛素，葡萄糖和上述三种生物标志物的水平，并持续每周一次直至实验结束（12周）。在糖尿病动物中，观察到血清β2M，BUN，Cr和葡萄糖水平显着增加，胰岛素水平显着下降。然而，与在第二天升高的Cr和BUN相比，在STZ注射后的第一天，β2M水平就升高了，这表明在糖尿病相关的肾脏并发症中，β2M可能比目前使用的生物标志物具有更高的诊断优势。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号