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首页> 美国卫生研究院文献>Saudi Journal of Biological Sciences >Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients
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Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients

机译：确定抗氧化状态和循环生化标志物在乙胺丁醇诱发的糖尿病和非糖尿病患者中毒性视神经病变的发病机理中的潜在作用

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The present study was designed to explore the antioxidative status and circulating biochemical markers having a potential role in the pathogenesis of ethambutol (EMB) induced toxic optic neuropathy (TON) among diabetic and non-diabetic patients.Fifty patients under complete therapy of EMB for tuberculosis were included in the present study. Inclusion criteria for patients were to receive EMB everyday during treatment, a dose of 25 mg/kg for initial 2 months and 15 mg/kg during the rest of therapy period. We conducted color vision and visual acuity test for all patients.Fifteen out of fifty EMB induced TON patients, were found to be diabetic. Color vision and visual acuity test results were evaluated for diabetic and non-diabetic as well as twenty age matched controls. The results demonstrated a significant pattern of circulating biochemical markers between the studied groups. Data regarding hematological (RBC, p value = 0.02; Hemoglobin, p value = 0.02), hepatic (total bilirubin, p value = 0.01), renal (urea, p value = 0.03; creatinine, p value = 0.007), lipid (total cholesterol, p value = 0.01; total triglycerides, p value = 0.03) and antioxidative (superoxide dismutase, p value = 0.005; glutathione, p value = 0.02; catalase, p value = 0.02) profile showed a highly significant difference among the studied groups specially patients with diabetes. Malondialdehyde (MDA) level had gone significantly up in diabetic TON patients (p value = 0.02), in comparison to other antioxidants and vitamins (Vit). Vit-A, E, B1, B12 and Zinc seem to be playing a major role in the pathogenesis of TON, specially Vit-E and B1 surpassed all the antioxidants as having highly significant inverse relationships with MDA (MDA vs Vit-E, r = −0.676** and MDA vs Vit-B1, r = −0.724** respectively).We conclude that during the ethambutol therapy the decreased levels of Vit-E and Vit-B1 possibly play a role in the development of TON and may be used as therapeutic agents to lessen the deleterious effects of ethambutol.
机译：本研究旨在探讨在糖尿病和非糖尿病患者中乙胺丁醇（EMB）诱发中毒性视神经病变（TON）发病机理中可能具有抗氧化作用的状态和循环生化标志物.50例接受EMB完全治疗的结核病患者被纳入本研究。患者的入选标准是在治疗期间每天接受EMB，最初2个月剂量为25 mg / kg，在其余治疗期间为15 mg / kg。我们对所有患者进行了色觉和视敏度测试。在50名EMB诱发的TON患者中，有15名患有糖尿病。评估了糖尿病和非糖尿病患者以及二十个年龄相匹配的对照组的色觉和视力测试结果。结果证明了研究组之间循环生化标记物的显着模式。血液学数据（RBC，p值= 0.02;血红蛋白，p值= 0.02），肝（总胆红素，p值= 0.01），肾脏（尿素，p值= 0.03;肌酐，p值= 0.007），脂质（总计胆固醇，p值= 0.01;总甘油三酸酯，p值= 0.03）和抗氧化（超氧化物歧化酶，p值= 0.005;谷胱甘肽，p值0.02;过氧化氢酶，p值0.02）之间的差异在研究组之间特别是糖尿病患者。与其他抗氧化剂和维生素（Vit）相比，糖尿病TON患者的丙二醛（MDA）水平显着上升（p值= 0.02）。 Vit-A，E，B1，B12和锌似乎在TON的发病机理中起着重要作用，特别是Vit-E和B1与所有抗氧化剂的相互作用都超过了MDA，与MDA呈极显着的负相关关系（MDA与Vit-E，r = −0.676 ** 和MDA与Vit-B1的关系，r分别为−0.724 ** ）。我们得出结论，在乙胺丁醇治疗期间，Vit-E和Vit-B1可能在TON的发展中发挥作用，可用作减轻乙胺丁醇的有害作用的治疗剂。

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