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首页> 美国卫生研究院文献>Saudi Pharmaceutical Journal : SPJ >Reduction of Animal Sacrifice in Biomedical Science Research through Alternative Design of Animal Experiments
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Reduction of Animal Sacrifice in Biomedical Science Research through Alternative Design of Animal Experiments

机译：通过动物实验的替代设计减少生物医学科学研究中的动物牺牲

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Various upcoming techniques can be used in replacement of experiments requiring animal sacrifice or products of animal sacrifice. In many instances these techniques provide more reproducibility and control of parameter, compared to experiments involving animal or animal products. Use of these techniques can avoid the question of the animal sacrifice during experiment and subsequently permission of ethical approval. In silico simulation, informatics, 3D cell culture models, organ-on-chips are some innovative technology which can reduce the number of animals sacrifice. Scientist evolved some innovative culture procedures and production of animal friendly affinity reagents which are free from the product of animal sacrifice. Direct investigation on human body for treatment as well as further research, electronic health record is also helpful in the reduction of animals sacrifice in biomedical investigations. These techniques and strategies of research can be more cost effective as well as more relevant to various issues related to the human health. Some medical blunder has also been reported after the successful testing of drugs on animal’s model. Hence, the reliability of animal experiment in context with human health is questionable.Alternative to animal experiments help to reduce the number of animals required for research up to certain extent but is not able to eliminate the need for animals in research completely. Wisely use of animals in teaching & research is expected and the importance of animal experimentation in futuristic development in life science cannot be ignored.
机译：各种即将出现的技术可用于替代需要动物处死或动物处死产物的实验。与涉及动物或动物产品的实验相比，在许多情况下，这些技术可提供更高的可重复性和参数控制。使用这些技术可以避免在实验过程中牺牲动物以及随后获得伦理批准的问题。在计算机模拟，信息学，3D细胞培养模型，片上器官是一些创新技术，可以减少动物牺牲的数量。科学家改良了一些创新的培养程序，并生产了无动物牺牲品的动物亲和试剂。对人体进行直接调查以进行治疗以及进一步的研究，电子健康记录还有助于减少生物医学调查中动物的牺牲。这些研究技术和策略可以更具成本效益，并且与与人类健康有关的各种问题更加相关。在动物模型上成功测试药物后，也有医学上的失误报道。因此，动物实验在人类健康方面的可靠性值得怀疑。动物实验的替代方法在一定程度上有助于减少研究所需的动物数量，但不能完全消除对动物的研究需求。期望在教学和研究中明智地使用动物，并且动物实验在生命科学的未来发展中的重要性不可忽视。

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