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TRX-LOGOS - a graphical tool to demonstrate DNA information content dependent upon backbone dynamics in addition to base sequence

机译：TRX-LOGOS-一种图形工具用于展示除碱基序列外还依赖于骨架动力学的DNA信息含量

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BackgroundIt is now widely-accepted that DNA sequences defining DNA-protein interactions functionally depend upon local biophysical features of DNA backbone that are important in defining sites of binding interaction in the genome (e.g. DNA shape, charge and intrinsic dynamics). However, these physical features of DNA polymer are not directly apparent when analyzing and viewing Shannon information content calculated at single nucleobases in a traditional sequence logo plot. Thus, sequence logos plots are severely limited in that they convey no explicit information regarding the structural dynamics of DNA backbone, a feature often critical to binding specificity.

机译：背景技术现在广泛接受的是，定义DNA-蛋白质相互作用的DNA序列在功能上取决于DNA骨架的局部生物物理特征，这对于定义基因组中的结合相互作用的位点（例如DNA形状，电荷和内在动力学）很重要。但是，当在传统序列徽标图中分析和查看在单个核碱基处计算的香农信息含量时，DNA聚合物的这些物理特征并不直接明显。因此，序列徽标图受到严重限制，因为它们不传达有关DNA骨架结构动力学的明确信息，而DNA骨架是通常对结合特异性至关重要的特征。

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期刊名称 Source Code for Biology and Medicine
作者
Connor H. Fortin; Katharina V. Schulze; Gregory A. Babbitt;
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作者单位

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年(卷),期 2015(10),-1
年度 2015
页码 10
总页数 11
原文格式 PDF
正文语种
中图分类生物学;
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专利

1. TRX-LOGOS - a graphical tool to demonstrate DNA information content dependent upon backbone dynamics in addition to base sequence [J] . Connor H. Fortin, Katharina V. Schulze, Gregory A. Babbitt Source Code for Biology Medicine . 2015,第1期

机译：TRX-LOGOS-一种图形工具，用于展示除碱基序列外还依赖于骨架动态的DNA信息内容
2. Three 3D graphical representations of DNA primary sequences based on the classifications of DNA bases and their applications. [J] . Xie G, Mo Z Journal of Theoretical Biology . 2011,第1期

机译：基于DNA碱基的分类及其应用的DNA主序列的三个3D图形表示。
3. The use of thioglycollate to demonstrate DNA AP (apurinic/apyrimidinic-site) lyase activities. Biological consequences of thiol addition to the 5′ product of a β-elimination reaction at an AP site in DNA [J] . S Bricteux-Grégoire, W G Verly The biochemical journal . 1991,第3期

机译：巯基乙酸盐用于证明DNA AP（尿嘧啶/嘧啶位）裂解酶的活性。在DNA的AP位点将硫醇添加到β-消除反应的5'产物中的生物学后果
4. 2D-dynamic Representation of DNA Sequences as a Graphical Tool in Bioinformatics [C] . D. Bielinska-Waz, P. Waz International Conference for Promoting the Application of Mathematics in Technical and Natural Sciences . 2016

机译：DNA序列的2D动态表示作为生物信息学中的图形工具
5. Part I. NMR studies of sequence-specific transition metal binding to biologically important DNA sequences cleaved during the iron-mediated Fenton reaction. Part II. DNA sequence-dependent steady-state and time-resolved fluorescence characteristics of 2-aminopurine. [D] . Rai, Priyamvada. 2003

机译：第一部分。NMR研究序列特异性过渡金属与铁介导的Fenton反应过程中裂解的生物学重要DNA序列的结合。第二部分2-氨基嘌呤的DNA序列依赖性稳态和时间分辨荧光特征。
6. Three 3D graphical representations of DNA primary sequences based on the classifications of DNA bases and their applications [O] . Guosen Xie, Zhongxi Mo -1

机译：基于DNA碱基的分类及其应用的3D DNA初级序列的3D图形表示
7. TRX-LOGOS - a graphical tool to demonstrate DNA information content dependent upon backbone dynamics in addition to base sequence [O] . Connor H. Fortin, Katharina V. Schulze, Gregory A. Babbitt 2015

机译：TRX-LOGOS-一种图形工具，用于展示除碱基序列外还依赖于骨架动力学的DNA信息含量
8. Sequence Dependent Structure and Thermodynamics of DNA Oligonucleotides and Polynucleotides: Uv Melting and NMR (Nuclear Magnetic Resonance) Studies [R] . Aboul-ela, F. M. 1987

机译：DNa寡核苷酸和多核苷酸的序列依赖结构和热力学：Uv熔化和NmR（核磁共振）研究

TRX-LOGOS - a graphical tool to demonstrate DNA information content dependent upon backbone dynamics in addition to base sequence

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