• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Molecular Brain >Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes
【2h】

Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes

机译：发射机释放概率的上调可改善突触模拟信号向神经元数字尖峰的转换

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Action potentials at the neurons and graded signals at the synapses are primary codes in the brain. In terms of their functional interaction, the studies were focused on the influence of presynaptic spike patterns on synaptic activities. How the synapse dynamics quantitatively regulates the encoding of postsynaptic digital spikes remains unclear. We investigated this question at unitary glutamatergic synapses on cortical GABAergic neurons, especially the quantitative influences of release probability on synapse dynamics and neuronal encoding. Glutamate release probability and synaptic strength are proportionally upregulated by presynaptic sequential spikes. The upregulation of release probability and the efficiency of probability-driven synaptic facilitation are strengthened by elevating presynaptic spike frequency and Ca2+. The upregulation of release probability improves spike capacity and timing precision at postsynaptic neuron. These results suggest that the upregulation of presynaptic glutamate release facilitates a conversion of synaptic analogue signals into digital spikes in postsynaptic neurons, i.e., a functional compatibility between presynaptic and postsynaptic partners.
机译：神经元的动作电位和突触的分级信号是大脑的主要代码。就它们的功能相互作用而言，研究集中于突触前突触模式对突触活动的影响。突触动力学如何定量调节突触后数字峰值的编码仍不清楚。我们在皮质GABA能神经元的单一谷氨酸能突触中研究了这个问题，尤其是释放概率对突触动力学和神经元编码的定量影响。谷氨酸释放的可能性和突触强度被突触前连续尖峰成比例上调。通过提高突触前突触频率和Ca 2 + 可以增强释放概率的上调和概率驱动的突触促进的效率。释放概率的上调提高了突触后神经元的突波能力和定时精度。这些结果表明，突触前谷氨酸释放的上调促进突触后神经元中突触类似信号向数字突波的转换，即突触前和突触后伙伴之间的功能相容性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号