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首页> 美国卫生研究院文献>Molecular and Cellular Biology >Upregulation of the Drosophila Friend of GATA Gene u-shaped by JAK/STAT Signaling Maintains Lymph Gland Prohemocyte Potency
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Upregulation of the Drosophila Friend of GATA Gene u-shaped by JAK/STAT Signaling Maintains Lymph Gland Prohemocyte Potency

机译：JAK / STAT信号介导的U型GATA基因的果蝇朋友的上调维持了淋巴腺前体淋巴细胞的效力

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Studies using Drosophila melanogaster have contributed significantly to our understanding of the interaction between stem cells and their protective microenvironments or stem cell niches. During lymph gland hematopoiesis, the Drosophila posterior signaling center functions as a stem cell niche to maintain prohemocyte multipotency through Hedgehog and JAK/STAT signaling. In this study, we provide evidence that the Friend of GATA protein U-shaped is an important regulator of lymph gland prohemocyte potency and differentiation. U-shaped expression was determined to be upregulated in third-instar lymph gland prohemocytes and downregulated in a subpopulation of differentiating blood cells. Genetic analyses indicated that U-shaped maintains the prohemocyte population by blocking differentiation. In addition, activated STAT directly regulated ush expression as evidenced by results from loss- and gain-of-function studies and from analyses of the u-shaped hematopoietic cis-regulatory module. Collectively, these findings identify U-shaped as a downstream effector of the posterior signaling center, establishing a novel link between the stem cell niche and the intrinsic regulation of potency and differentiation. Given the functional conservation of Friend of GATA proteins and the role that GATA factors play during cell fate choice, these factors may regulate essential functions of vertebrate hematopoietic stem cells, including processing signals from the stem cell niche.
机译：使用果蝇的研究为我们对干细胞与其保护性微环境或干细胞生态位之间相互作用的理解做出了重要贡献。在淋巴组织造血过程中，果蝇后部信号传导中心起干细胞的作用，通过刺猬和JAK / STAT信号传导维持血细胞多能性。在这项研究中，我们提供的证据表明，GATA蛋白之友的U型蛋白是淋巴腺前血细胞能力和分化的重要调节剂。确定U形表达在三龄淋巴腺前血细胞中上调，而在分化血细胞亚群中下调。遗传分析表明，U形通过阻止分化来维持血红细胞的数量。此外，激活的STAT直接调节ush表达，功能丧失和获得功能研究的结果以及u型造血顺式调节模块的分析结果都证明了这一点。总的来说，这些发现确定了U型是后信号中心的下游效应子，从而在干细胞利基与效能和分化的内在调节之间建立了新的联系。鉴于Friend GATA蛋白的功能保守性以及GATA因子在细胞命运选择过程中的作用，这些因子可能调节脊椎动物造血干细胞的基本功能，包括处理来自干细胞小生境的信号。

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