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Analysis of Rho-PKN Signaling in Prostate Cancer Using Drosophila Genetics

机译：利用果蝇遗传学分析前列腺癌中Rho-pKN信号

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The Rho effector protein kinase N (PKN) has been implicated in prostate cancer. To study the role of PKN andclosely related PRK2 in prostate cancer progression, lentiviral small hairpin RNA constructs have been obtained andwhich knock down expression of PKN and PRK2 in human cells. The constructs will be introduced into prostatecancer cells to study the role of PKN and PRK2 in cellular processes related to tumorigenesis. To identify novelcomponents of the PKN signaling pathway, a genetic screen has been undertaken in the fruit fly Drosophilamelanogaster, which has a well-conserved Pkn gene. So far two potential genetic interactors for Pkn have beenidentified: CKlla-i3 and RHOGAP71E. Screening is still ongoing so more interactors may be discovered. For anyinteractors identified, the mechanism of interaction with Pkn and the conservation of the pathway in humans the willbe investigated. Taken together these studies should lead to an increased understanding of a poorly characterizedsignaling pathway in flies and humans which may play a role in prostate cancer progression.

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Betson, M. E.;
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年度 2006
页码 1-17
总页数 17
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Genetics; Drosophila; Prostate cancer; Proteins; Neoplasms; Markers; Androgens; Growth(Physiology); Receptor sites(Physiology); Medical research; Cells(Biology);

机译：遗传学;果蝇;前列腺癌;蛋白质;肿瘤;标记物;雄激素;生长（生理学）;受体位点（生理学）;医学研究;细胞（生物学）;

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1. A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer [J] . Scarbrough Peter M., Weber Rachel Palmieri, Iversen Edwin S., Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2016,第1期

机译：肺癌，卵巢癌，前列腺癌，乳腺癌和结直肠癌的DNA修复和DNA损伤信号传导途径的跨癌遗传关联分析
2. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease [J] . TeerlinkC.C., ThibodeauS.N., McDonnellS.K., Human Genetics . 2014,第3期

机译：国际前列腺癌遗传学协会对9,560例前列腺癌病例的关联分析证实了已报道的与前列腺癌相关的SNP在家族性疾病中的作用
3. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease [J] . TeerlinkC.C., ThibodeauS.N., McDonnellS.K., Human Genetics . 2014,第3期

机译：来自前列腺癌遗传学国际联盟的9,560个前列腺癌病例的关联分析证实了报告的前列腺癌相关SNP对家族疾病的作用
4. Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer [C] . Ralph Schiess, I. Cima, P. Wild, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：癌症遗传学引导的血清生物标志物签名鉴定前列腺癌的诊断和预后
5. Fibroblast growth factor signaling in prostate stem cells and prostate cancer [D] . Huang, Yanqing. 2015

机译：前列腺干细胞和前列腺癌中的成纤维细胞生长因子信号转导
6. A Cross-Cancer Genetic Association Analysis of the DNA repair and DNA Damage Signaling Pathways for Lung Ovary Prostate Breast and Colorectal Cancer [O] . Peter M. Scarbrough, Rachel Palmieri Weber, Edwin S. Iversen, -1

机译：肺癌卵巢癌前列腺癌乳腺癌和结直肠癌的DNA修复和DNA损伤信号传导途径的跨癌遗传关联分析
7. A Cross-Cancer Genetic Association Analysis of the DNA repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast and Colorectal Cancer [O] . Scarbrough, P M, Weber, R P, Iversen, E S, 2015

机译：肺癌，卵巢癌，前列腺癌，乳腺癌和结直肠癌的DNa修复和DNa损伤信号通路的跨癌症遗传关联分析

Analysis of Rho-PKN Signaling in Prostate Cancer Using Drosophila Genetics

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