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A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids sphingolipids and plasmalogens

机译：使用质谱技术对胰岛β细胞进行全面的脂质组学筛选确定了葡萄糖刺激的中性脂质鞘脂和缩醛磷脂代谢的新特征

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摘要

ObjectiveGlucose promotes lipid remodelling in pancreatic β-cells, and this is thought to contribute to the regulation of insulin secretion, but the metabolic pathways and potential signalling intermediates have not been fully elaborated.

机译：Objective-Glucose促进胰腺β细胞的脂质重塑，这被认为有助于调节胰岛素分泌，但尚未完全阐明其代谢途径和潜在的信号传导中间体。

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期刊名称 Molecular Metabolism
作者
Gemma L. Pearson; Natalie Mellett; Kwan Yi Chu; Ebru Boslem; Peter J. Meikle; Trevor J. Biden;
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作者单位

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年(卷),期 2016(5),6
年度 2016
页码 404–414
总页数 11
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Pancreatic β-cell Insulin secretion Diacylglycerol Monacylglycerol Ceramide Plasmalogen;

机译：胰岛β细胞;胰岛素分泌;二酰基甘油;单酰基甘油;神经酰胺;血浆;

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专利

1. A comprehensive lipidomic screen of pancreatic @b-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens [J] . Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, Molecular Metabolism . 2016,第6期

机译：使用质谱技术对胰脏@b细胞进行全面的脂质组学筛选，确定了葡萄糖刺激的中性脂质，鞘脂和缩醛磷脂代谢的新特征
2. Separation of Glycolipids/Sphingolipids from Glycerophospholipids on TiO2 Coating in Aprotic Solvent for Rapid Comprehensive Lipidomic Analysis with Liquid Microjunction Surface Sampling-Mass Spectrometry [J] . Huang Zehui, Wu Qian, Lu Hongmei, Analytical chemistry . 2020,第16期

机译：用液体微型表面采样 - 质谱法快速综合脂质分析，将甘油磷脂从甘油磷脂中的甘油磷脂分离在TiO2涂料中的甘油磷脂。
3. A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking [J] . Amanda?M. Preston, Anna?K. Busch, Clarissa Bartley, The biochemical journal . 2011,第1期

机译：棕榈酸酯处理的MIN6β细胞的脂质组学筛选将鞘脂代谢物与内质网（ER）应激和蛋白运输受损联系起来
4. A novel platform for comprehensive lipidomics screening of biological and human clinical samples based on MALDI-QIT-TOF-multistage tandem-mass spectrometry [C] . Gerald Stubiger, Wolfgang Werther, Ian Brookhouse, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：基于Maldi-QIT-TOF - 多级串联光谱法的生物和人类临床样品综合脂质血型筛选的新平台
5. Mass spectrometry strategies for comprehensive lipidome analysis of colorectal cancer cells and their secreted exosomes. [D] . Fhaner, Cassie J. 2014

机译：用于大肠癌细胞及其分泌的外泌体的全面脂质组分析的质谱策略。
6. The Combination of Whole Cell Lipidomics Analysis and Single Cell Confocal Imaging of Fluidity and Micropolarity Provides Insight into Stress-Induced Lipid Turnover in Subcellular Organelles of Pancreatic Beta Cells [O] . Giuseppe Maulucci, Ofir Cohen, Bareket Daniel, 2019

机译：全细胞脂质组学分析与流动性和微极性的单细胞共聚焦成像相结合为深入了解胰腺β细胞亚细胞器中压力诱导的脂质转换
7. A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens [O] . Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, 2016

机译：使用质谱法对胰腺β细胞进行全面的脂质组学筛选，定义了葡萄糖刺激的中性脂质，鞘脂和缩醛磷脂转换的新特征。

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids sphingolipids and plasmalogens

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