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首页> 美国卫生研究院文献>Molecular Neuropsychiatry >Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder
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Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder

机译：NCAN rs1064395与双相情感障碍之间存在关联的进一步证据

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摘要

Genome-wide association studies suggest that rs1064395 in the neurocan gene (NCAN) is a potential risk factor for bipolar disorder (BPD), and further replication analyses in larger independent samples are needed. We herein analyzed rs1064395 in a Han Chinese sample of 1,146 BPD cases and 2,031 controls, followed by a meta-analysis of BPD samples from worldwide populations including a total of 15,318 cases and 91,990 controls. The meta-analysis found that rs1064395 showed a genome-wide significant association with BPD (p = 4.92 × 10–9, OR = 1.126 for the A allele), although it did not reach the significance level in the Han Chinese sample (p = 0.415, OR = 1.070 for the A allele). We also examined the association between the single nucleotide polymorphisms and major depressive disorder (MDD) given the presumed genetic overlap between BPD and MDD, and rs1064395 was also associated with MDD (p = 0.0068, OR = 1.067 for the A allele) in a meta-analysis of 14,543 cases and 14,856 controls. Our data provide further evidence for the involvement of NCAN in the genetic susceptibility to BPD and also implicate its broader role in major mood disorders.
机译：全基因组关联研究表明，神经罐基因（NCAN）中的rs1064395是双相情感障碍（BPD）的潜在危险因素，需要在较大的独立样本中进行进一步的复制分析。我们在本文中分析了汉族1146名BPD病例和2031名对照的汉族样本中的rs1064395，然后对来自全球人群的BPD样本进行了荟萃分析，包括15318名病例和91990名对照。荟萃分析发现，rs1064395与BPD之间存在全基因组显着关联（p = 4.92×10 –9 ，对于A等位基因，OR = 1.126），尽管在BPD中未达到显着水平。汉族样本（p等位基因为p = 0.415，OR = 1.070）。考虑到BPD和MDD之间的遗传重叠，我们还检查了单核苷酸多态性与主要抑郁症（MDD）之间的关联，并且rs1064395也与meta上的MDD（p = 0.0068，OR = 1.067）相关。 -分析了14,543例病例和14,856例对照。我们的数据为NCAN参与BPD的遗传易感性提供了进一步的证据，也暗示了NCAN在主要情绪障碍中的更广泛作用。

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