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首页> 美国卫生研究院文献>Molecules >Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active N-phthaloyl Valine Moieties in the Hepatic Cytochrome P450 System in Male Rats
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Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active N-phthaloyl Valine Moieties in the Hepatic Cytochrome P450 System in Male Rats

机译：含氧化还原活性N-邻苯二甲酰缬氨酸部分的新型芳酰胺纳米粒子在肝细胞色素P450系统中的抗氧化活性。

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摘要

We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P450, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome C-reductase. Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl4 on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl4 decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (•CCl3) upon the liver through inhibition of the cytochrome P450 system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens.
机译：我们报告了含有手性N-邻苯二甲酰缬氨酸部分的芳酰胺纳米颗粒的合成及其对细胞色素P450，酰胺基N-脱甲基酶，苯胺-4-羟化酶的肝含量的抗氧化活性，并诱导了细胞色素b5和烟酰胺腺嘌呤二核苷酸磷酸的肝含量（ NADPH）细胞色素C还原酶。获得了作为良好分离的球形纳米颗粒的聚合物，而经由含芳酰胺的吡啶的H键组织的高度聚集的颗粒导致了薄层的形成。研究了纳米颗粒和四氯化碳对雄性大鼠肝脏酶活性和硫代巴比妥酸反应性物质（TBARS）水平的影响。在给予CCl4之前，用聚酰胺对大鼠进行预处理可降低被测酶的肝含量。剂量可通过抑制细胞色素P450系统降低（CCl3）对肝脏的毒性作用。抑制这种代谢酶可以降低化学致癌物的致癌作用。

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