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首页> 美国卫生研究院文献>Molecules >Analysis of Chemical Constituents in Wuzi-Yanzong-Wan by UPLC-ESI-LTQ-Orbitrap-MS
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Analysis of Chemical Constituents in Wuzi-Yanzong-Wan by UPLC-ESI-LTQ-Orbitrap-MS

机译：UPLC-ESI-LTQ-Orbitrap-MS法分析乌自燕宗湾中的化学成分

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摘要

Wuzi-Yanzong-Wan (WZYZW), a classical traditional Chinese medicine (TCM) prescription containing Fructus Lych, Semen Cuscutae (fried), Fructus Rubi, Fructus Schisandrae chinensis (steamed) and Semen Plantaginis (fried with salt), is widely used to treat impotence, sterility, spermatorrhea, premature ejaculation, lumbago and post-micturation dribble. However, the chemical profile of WZYZW has not been established yet. In this work, a rapid and sensitive method for systematically screening and identifying the chemical constituents of WZYZW in both positive and negative ion modes using Ultra-Performance LC coupled with ESI-linear ion trap-Orbitrap tandem mass spectrometry (UPLC-ESI-LTQ-Orbitrap-MS) has been developed. Based on the chromatographic and spectrometric data, and referring to the literature, we could tentatively identify 106 compounds, including organic acids, flavonoids, phenylpropanoids, alkaloids and terpenoids. Fourteen ingredients from Fructus Lych were identified, while 10 ingredients were from Semen Cuscutae (fried), 33 ingredients were from Fructus Rubi, 37 ingredients were from Fructus Schisandrae chinensis (steamed), and 20 ingredients were from Semen Plantaginis (fried with salt). The results may provide essential data for further quality control, pharmacological research and clinical evaluation of WZYZW. Furthermore, this study indicates the developed approach based on UPLC-ESI-LTQ-Orbitrap-MS is suitable for characterizing the chemical profiles of TCM prescriptions. This is the first report to provide a comprehensive analysis of the chemical constituents of WZYZW.
机译：传统的中药处方-乌子-延宗万（WZYZW）广泛用于制作to子、,子（油炸），F子，五味子（蒸）和车前子（用盐炒）。治疗阳imp，不育，遗精，早泄，腰痛和排尿后运球。但是，WZYZW的化学特征尚未建立。在这项工作中，采用超高效液相色谱与ESI-线性离子阱-Orbitrap串联质谱（UPLC-ESI-LTQ-U）结合使用的快速灵敏的方法，可以在正离子和负离子模式下系统地筛选和鉴定WZYZW的化学成分Orbitrap-MS）已开发。根据色谱和光谱数据，并参考文献，我们可以初步鉴定出106种化合物，包括有机酸，类黄酮，苯基丙烷，生物碱和萜类化合物。鉴定出了14种成分，其中10种成分来自10子（油炸），33种成分来自红Rub，37种成分来自北五味子（蒸），还有20种成分来自于Plantaginis（油炸）。结果可为WZYZW的进一步质量控制，药理研究和临床评估提供必要的数据。此外，这项研究表明，基于UPLC-ESI-LTQ-Orbitrap-MS的已开发方法适用于表征中药处方的化学特征。这是第一份全面分析WZYZW化学成分的报告。

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