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Synthesis of Novel Symmetrical 14-Disubstituted 123-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation

机译：通过点击化学合成新型对称的14-二取代的123-双三唑衍生物及其生物学评价

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摘要

A series of symmetric bis-1,2,3-triazole compounds >2–>5(>a–>f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by ¹H-NMR and ¹³C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity of these compounds (AChE inhibition, DPPH and SOD activities) was evaluated. Compound >2f was found to show the highest AChE inhibition activity of all compounds, while compound >3b showed a strong inhibitory effect on DPPH radical and compound >2a was the most effective of all compounds for SOD activity. All synthesized compounds were found to possess moderate antibacterial activity against the bacteria E. coli and Y.pseudotuberculosis.

机译：一系列对称的双1,2,3-三唑化合物> 2 – > 5 （> a – > f ）通过点击化学合成了潜在的抗氧化剂。它们的结构通过^{1 H-NMR和^{13 C-NMR证实。所有合成的化合物均经过抗氧化剂和抗菌测定。评价了这些化合物的抗氧化活性（AChE抑制，DPPH和SOD活性）。发现化合物> 2f 对所有化合物均显示出最高的AChE抑制活性，而化合物> 3b 对DPPH自由基和化合物> 2a 具有较强的抑制作用在所有化合物中对SOD活性最有效。发现所有合成的化合物对细菌大肠杆菌和假结核耶尔森氏菌均具有中等的抗菌活性。}}

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期刊名称 Molecules
作者
Esra Düğdü; Dilek Ünlüer; Fatih Çelik; Kemal Sancak; Şengül Alpay Karaoğlu; Arzu Özel;
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作者单位

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年(卷),期 2016(21),5
年度 2016
页码 659
总页数 13
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
123-triazole; 13-dipolar cycloaddition; antioxidant activity; antimicrobial activity;

机译：123-三唑;13-偶极环加成;抗氧化活性抗菌活性;

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1. Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via 'Click Chemistry' and Their Biological Evaluation [J] . Dugdu Esra, Unluer Dilek, Celik Fatih, Molecules . 2016,第5期

机译：通过“点击化学”合成新型对称的1,4-二取代的1,2,3-双三唑对称衍生物及其生物学评价
2. Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation [J] . Esra Dü?dü, Dilek ünlüer, Fatih ?elik, Molecules . 2016,第5期

机译：通过“点击化学”合成新型对称的1,4-二取代的1,2,3-双三唑衍生物及其生物学评价
3. Synthesis and biological evaluation of novel Tc-99m(CO)(3) labeled glucose derivatives prepared by click chemistry route [J] . Liu Teli, Gan Qianqian, Zhang Junbo Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry . 2016,第3期

机译：通过点击化学法制备的新型Tc-99m（CO）（3）标记的葡萄糖衍生物的合成及生物学评价
4. DESIGN,SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-PHENYLISOXAZOLO5,4-DPYRIMIDINE DERIVATIVES AS ANTICANCER AGENTS [C] . Nikhil Gaikwad, Y.V.Madhavi Conference on Drug Design and Discovery Technologies . 2020

机译：3-苯基异恶唑的设计，合成和生物学评价5,4-D嘧啶衍生物作为抗癌剂
5. Bifunctional cyclooctynes in copper-free click chemistry for applications in radionuclide chemistry and 4-alkylpyridine derivatives in intramolecular dearomatization and heterocycle synthesis. [D] . Guddehalli Parameswarappa, Sharavathi. 2011

机译：无铜点击化学中的双功能环辛炔，用于放射性核素化学中； 4-烷基吡啶衍生物用于分子内脱芳香化和杂环合成中。
6. Improved synthesis and biological evaluation of chelator-modified α-MSH analogues prepared by copper-free click chemistry [O] . Nicholas J. Baumhover, Molly E. Martin, Sharavathi G. Parameswarappa, -1

机译：通过铜无咔哒化学制备的螯合剂改性α-MSH类似物的合成和生物学评估
7. Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation [O] . Esra Düğdü, Dilek Ünlüer, Fatih Çelik, 2016

机译：通过“点击化学”合成新型对称1,4-二取代1,2,3-双三唑衍生物及其生物学评价

Synthesis of Novel Symmetrical 14-Disubstituted 123-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation

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