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首页> 美国卫生研究院文献>Molecules >Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys
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Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys

机译：富含天冬酰胺的绿色如意宝提取物可降低高脂饮食诱导的糖尿病黑长尾猴的低密度脂蛋白胆固醇和氧化状态

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Type 2 diabetic patients possess a two to four-fold-increased risk for cardiovascular diseases (CVD). Hyperglycemia, oxidative stress associated with endothelial dysfunction and dyslipidemia are regarded as pro-atherogenic mechanisms of CVD. In this study, high-fat diet-induced diabetic and non-diabetic vervet monkeys were treated with 90 mg/kg of aspalathin-rich green rooibos extract (Afriplex GRT) for 28 days, followed by a 1-month wash-out period. Supplementation showed improvements in both the intravenous glucose tolerance test (IVGTT) glycemic area under curve (AUC) and total cholesterol (due to a decrease of the low-density lipoprotein [LDL]) values in diabetics, while non-diabetic monkeys benefited from an increase in high-density lipoprotein (HDL) levels. No variation of plasma coenzyme Q10 (CoQ10) were found, suggesting that the LDL-lowering effect of Afriplex GRT could be related to its ability to modulate the mevalonate pathway differently from statins. Concerning the plasma oxidative status, a decrease in percentage of oxidized CoQ10 and circulating oxidized LDL (ox-LDL) levels after supplementation was observed in diabetics. Finally, the direct correlation between the amount of oxidized LDL and total LDL concentration, and the inverse correlation between ox-LDL and plasma CoQ10 levels, detected in the diabetic monkeys highlighted the potential cardiovascular protective role of green rooibos extract. Taken together, these findings suggest that Afriplex GRT could counteract hyperglycemia, oxidative stress and dyslipidemia, thereby lowering fundamental cardiovascular risk factors associated with diabetes.
机译：2型糖尿病患者的心血管疾病（CVD）风险增加了2到4倍。高血糖，与内皮功能障碍有关的氧化应激和血脂异常被认为是CVD的促动脉粥样硬化机制。在这项研究中，高脂饮食诱导的糖尿病和非糖尿病性黑长尾猴用90 mg / kg富含天冬氨酸的绿色如意宝提取物（Afriplex GRT）处理28天，然后进行1个月的清除期。补充剂显示糖尿病患者的静脉葡萄糖耐量试验（IVGTT）曲线下血糖面积（AUC）和总胆固醇（由于低密度脂蛋白[LDL]降低）值均有改善，而非糖尿病猴则受益于增加高密度脂蛋白（HDL）的水平。没有发现血浆辅酶Q10（CoQ10）的变化，表明Afriplex GRT的LDL降低作用可能与其调节他汀类药物的甲羟戊酸途径不同有关。关于血浆氧化状态，在糖尿病患者中观察到补充后的氧化CoQ10百分比和循环氧化LDL（ox-LDL）水平降低。最后，在糖尿病猴中检测到氧化的LDL量与总LDL浓度之间的直接相关性以及ox-LDL与血浆CoQ10水平之间的反相关性突出了绿色如意宝的潜在心血管保护作用。综上所述，这些发现表明，Afriplex GRT可以抵消高血糖，氧化应激和血脂异常，从而降低与糖尿病相关的基本心血管危险因素。

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